Singla Neeraj, Jandial Aditya, Sharma Nalin, Sharma Navneet, Bhatia Mandip, Behera Ashish
Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh, IND.
Cureus. 2022 Oct 14;14(10):e30302. doi: 10.7759/cureus.30302. eCollection 2022 Oct.
Background Sepsis is an emergency state in response to an infectious process ultimately leading to multiorgan dysfunction and death. There is an urgent need for sepsis detection methods, especially in emergency settings. To fill this gap, monocyte distribution width (MDW) was studied as an early indicator of sepsis. Aim To evaluate MDW as an early marker of sepsis. Material and methods This was a prospective observational study including critically ill adult patients who presented to the emergency department. MDW was measured using a DxH 900 Hematology Analyser (Beckman Coulter Inc., Miami, FL). Abnormal MDW (>20.0) was considered a predictor of sepsis. Results A total of 148 patients were included and categorized according to the Sepsis-2 and Sepsis-3 criteria, as having sepsis (25.6%), sepsis with shock (21.6%), and non-sepsis (52.8%). In patients with sepsis with and without shock, MDW was 28.28 ± 9.20 and 28.02 ± 9.01, respectively, significantly higher than in patients without sepsis (p < 0.001). The diagnostic accuracy value of MDW testing for early sepsis detection was highly significant (0.74, p < 0.000). Conclusion MDW can be used as a marker for the early prediction of sepsis.
脓毒症是机体对感染过程的一种紧急反应状态，最终可导致多器官功能障碍和死亡。迫切需要脓毒症检测方法，尤其是在急诊环境中。为填补这一空白，研究了单核细胞分布宽度（MDW）作为脓毒症的早期指标。目的：评估MDW作为脓毒症的早期标志物。材料与方法：这是一项前瞻性观察性研究，纳入了到急诊科就诊的成年危重症患者。使用DxH 900血液分析仪（贝克曼库尔特公司，佛罗里达州迈阿密）测量MDW。MDW异常（>20.0）被视为脓毒症的预测指标。结果：共纳入148例患者，并根据脓毒症-2和脓毒症-3标准进行分类，分为脓毒症组（25.6%）、脓毒症休克组（21.6%）和非脓毒症组（52.8%）。有休克和无休克的脓毒症患者的MDW分别为28.28±9.20和28.02±9.01，显著高于非脓毒症患者（p<0.001）。MDW检测用于早期脓毒症检测的诊断准确性值非常显著（0.74，p<0.000）。结论：MDW可作为脓毒症早期预测的标志物。
