Lu Yangyuxiao, Huang Hong, Chen Yuling, He Keren, Fang Mengqi, Xu Ye, Zhou Yuan, Tao Fangfang
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
J Cancer. 2025 Jul 28;16(11):3497-3512. doi: 10.7150/jca.118209. eCollection 2025.
Ovarian cancer (OC), the seventh most common cancer in women globally, is one of the most prevalent and lethal gynecological cancers. With a high degree of malignancy and a dismal prognosis, late-stage patients frequently experience relapses and metastases. Associated with this is the high drug resistance of OC, which is a common challenge in cancer treatment. Natural products have garnered increasing attention in tumor treatment due to their relatively high safety and stable sources. Previous studies have demonstrated that various active ingredients in natural products can impact the progression of OC through diverse molecular mechanisms. These mechanisms include inducing cell cycle arrest, regulating reactive oxygen species (ROS), modulating autophagy, promoting cell apoptosis, inhibiting proliferation, invasion, and migration of OC cells, and regulating the tumor immune microenvironment (TIME). This article comprehensively elucidates the mechanisms by which natural products combat ovarian cancer and highlights both the emerging opportunities and existing challenges in their development as effective therapeutic agents.
卵巢癌（OC）是全球女性中第七大常见癌症，是最普遍且致命的妇科癌症之一。其恶性程度高，预后不佳，晚期患者常出现复发和转移。与此相关的是OC的高耐药性，这是癌症治疗中的一个常见挑战。天然产物因其相对较高的安全性和稳定的来源，在肿瘤治疗中受到越来越多的关注。先前的研究表明，天然产物中的各种活性成分可通过多种分子机制影响OC的进展。这些机制包括诱导细胞周期停滞、调节活性氧（ROS）、调节自噬、促进细胞凋亡、抑制OC细胞的增殖、侵袭和迁移，以及调节肿瘤免疫微环境（TIME）。本文全面阐明了天然产物对抗卵巢癌的机制，并强调了其作为有效治疗药物开发中出现的机遇和现有挑战。
