Mozafaryan Mohammad Javad, Rezaei Pouria, Masoudpoor Fardin, Bahri Amirmohammad, Samini Mohammad, Farkhondeh Tahere, Pourhanifeh Mohammad Hossein, Samarghandian Saeed
Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran.
Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran.
Curr Med Chem. 2024 May 3. doi: 10.2174/0109298673290941240430171146.
Gynecological cancers, encompassing endometrial, ovarian, and cervical cancer, pose significant challenges in clinical practice, often marked by high mortality rates and treatment resistance. Despite advances in standard therapies, including chemoradiation and surgery, tumor recurrence and metastasis remain formidable obstacles. In this context, there is a pressing need to explore novel therapeutic strategies that offer improved efficacy and reduced side effects. Herbal medicine, particularly compounds like resveratrol, has garnered attention for its diverse biological properties, including anticancer effects. Resveratrol, a multipotential nutraceutical, holds promise in gynecological cancer therapy through its modulation of key cellular and molecular processes. This review aims to provide an overview of the current status, challenges, and opportunities in utilizing resveratrol for gynecological cancer treatment. We discuss its role in miRNA regulation, clinical trial findings, and the development of effective formulations. By elucidating the underlying mechanisms of resveratrol's anticancer effects and exploring innovative delivery systems, we aim to shed light on the potential avenues for optimizing its therapeutic benefits in gynecological cancers.
妇科癌症，包括子宫内膜癌、卵巢癌和宫颈癌，在临床实践中构成重大挑战，其特征通常是高死亡率和治疗耐药性。尽管包括放化疗和手术在内的标准疗法取得了进展，但肿瘤复发和转移仍然是巨大的障碍。在这种背景下，迫切需要探索能提高疗效并减少副作用的新型治疗策略。草药，特别是白藜芦醇等化合物，因其多样的生物学特性（包括抗癌作用）而受到关注。白藜芦醇是一种具有多种潜能的营养保健品，通过调节关键的细胞和分子过程，在妇科癌症治疗中具有前景。本综述旨在概述利用白藜芦醇治疗妇科癌症的现状、挑战和机遇。我们讨论了其在miRNA调节中的作用、临床试验结果以及有效制剂的开发。通过阐明白藜芦醇抗癌作用的潜在机制并探索创新的给药系统，我们旨在揭示优化其在妇科癌症治疗中疗效的潜在途径。
