Zhang Xin, Liu Xiaonan, Liu Yutong, Wei Xiaocen, Xing Mengzhen, Shi Lei, Zhang Linlin, Ma Yuning, Ma Yuxia, Zhang Han
Shandong Key Laboratory of Digital Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355 China.
Institute of Pharmacy (Institute of TCM Health Industrial Technology), Shandong University of Traditional Chinese Medicine Jinan 250355 China.
RSC Adv. 2025 Aug 18;15(35):29077-29088. doi: 10.1039/d5ra04027b. eCollection 2025 Aug 11.
Developing stimuli-responsive nanoplatforms is a promising strategy for controlling the release of targeted molecules. In this study, nitrobenzyl ester was chosen as a photoresponsive moiety to functionalize an organic bridged linker, facilitating the synthesis of a photoresponsive silane, namely 2-nitro-1,3-phenyl bis(methylene mercaptoacetate ester) bridged trimethoxysilane (SMS). Light-triggered degradable bridged polysilsesquioxane nanoparticles (SMPS) were achieved through hydrolysis-condensation reactions using SMS as a precursor in suspension polymerization. Upon irradiation at 365 nm for three hours, the particle size of SMPS decreased from 138 ± 20 nm to 103 ± 43 nm. The target molecule, evodiamine (Evo), was efficiently loaded onto SMPS through hydrophobic and electrostatic attractions, constructing a light-controlled release system, Evo@SMPS. The results of experiments demonstrate that this photoresponsive platform exhibits effective light-triggered release behavior upon 365 nm. Under an irradiation intensity of 100 mW cm for 12 hours, the cumulative release rate of Evo reached up to 92.3%, allowing precise control over the release amount, timing, and location of target molecules. This light-triggered degradable bridged polysilsesquioxane carrier platform with high biocompatibility holds significant potential and prospects for broad application in multifunctional controlled release systems.
开发刺激响应性纳米平台是控制靶向分子释放的一种有前景的策略。在本研究中，选择硝基苄酯作为光响应部分来功能化有机桥连连接体，促进了一种光响应性硅烷的合成，即2-硝基-1,3-苯基双（亚甲基巯基乙酸酯）桥连三甲氧基硅烷（SMS）。通过以SMS为前体在悬浮聚合中进行水解缩合反应，制备了光触发可降解的桥连聚倍半硅氧烷纳米颗粒（SMPS）。在365 nm照射3小时后，SMPS的粒径从138±20 nm减小到103±43 nm。通过疏水和静电吸引作用，将目标分子吴茱萸碱（Evo）有效地负载到SMPS上，构建了光控释放系统Evo@SMPS。实验结果表明，该光响应平台在365 nm光照下表现出有效的光触发释放行为。在100 mW cm的照射强度下照射12小时，Evo的累积释放率高达92.3%，能够精确控制目标分子的释放量、时间和位置。这种具有高生物相容性的光触发可降解桥连聚倍半硅氧烷载体平台在多功能控释系统中具有广阔的应用潜力和前景。
