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利用刺激响应型纳米粒子作为有效的药物传递系统。

Harnessing the Power of Stimuli-Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System.

机构信息

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 715, Saudi Arabia.

出版信息

Adv Mater. 2024 Jun;36(24):e2312939. doi: 10.1002/adma.202312939. Epub 2024 Mar 17.

Abstract

The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location, has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli-reactive nanosystems in biomedicine and outlines future development prospects.

摘要

寻求有效和可靠的药物输送方法,旨在将治疗剂递送到预期的位置,这在生物医药研究中提出了一个具有挑战性但又引人入胜的领域。智能药物输送系统的概念是一种不断发展的治疗方法,为将药物靶向特定目标或部位提供了范例。这些系统已经被开发出来,专门针对包括牙周炎、糖尿病、心脏病、炎症性肠病、类风湿性关节炎和不同类型癌症在内的多种慢性疾病,以靶向和调节治疗物质的给药。然而,仍需要进行大量全面的临床试验,以确定这些纳米系统对人体受试者的即时和持久影响。本综述深入探讨了不同药物输送载体的优势,旨在增强对其在满足当前医疗需求方面的适用性的理解。此外,它还涉及到这些刺激响应纳米系统在生物医学中的当前应用,并概述了未来的发展前景。

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