Peta Bhaktavatsalam, Mallela Srinivas Rao
Department of Pathophysiology, St. George's University School of Medicine, St. George's, GRD.
Department of Internal Medicine, Osmania General Hospital, Hyderabad, IND.
Cureus. 2025 Aug 24;17(8):e90871. doi: 10.7759/cureus.90871. eCollection 2025 Aug.
Spontaneous intracerebral hemorrhage (ICH) is a major cause of stroke-related morbidity and mortality, contributing to a substantial proportion of cases worldwide. Outcomes remain poor despite medical and surgical advances, highlighting the importance of identifying modifiable risk factors and reliable prognostic indicators.
To evaluate the clinical, radiological, and demographic risk factors associated with spontaneous ICH and identify predictors of prognosis among patients admitted to a tertiary care hospital in South India.
A prospective observational study was conducted on 40 patients with confirmed spontaneous ICH admitted to the Emergency Department of Mahatma Gandhi Memorial Hospital, Warangal. Data were collected on demographic variables, clinical presentation, risk factors (e.g., hypertension, alcohol, and smoking), and radiologic parameters (e.g., hematoma site, volume, and Glasgow Coma Scale (GCS) score). Outcomes were measured in terms of survival, neurological recovery, and GCS scores.
Hypertension was the most common risk factor, present in 28 (70%) patients. Alcohol consumption and smoking were also significantly associated with spontaneous ICH. Poor prognostic indicators included low initial GCS score, larger hematoma volume (>30 cm), presence of intraventricular hemorrhage, hydrocephalus, and midline shift. Mortality was higher in patients over 60 years and those with thalamic or brainstem bleeds.
Hypertension remains the primary modifiable risk factor for spontaneous ICH in this population. Initial GCS score, hematoma volume, and intraventricular extension are strong prognostic indicators. Early identification and targeted management of these factors may help improve outcomes.
自发性脑出血(ICH)是卒中相关发病和死亡的主要原因,在全球范围内占相当大比例的病例。尽管医学和外科取得了进展,但预后仍然很差,这凸显了识别可改变的危险因素和可靠的预后指标的重要性。
评估与自发性ICH相关的临床、影像学和人口统计学危险因素,并确定印度南部一家三级护理医院收治患者的预后预测因素。
对瓦朗加尔甘地纪念医院急诊科收治的40例确诊自发性ICH患者进行了一项前瞻性观察研究。收集了人口统计学变量、临床表现、危险因素(如高血压、饮酒和吸烟)以及影像学参数(如血肿部位、体积和格拉斯哥昏迷量表(GCS)评分)的数据。根据生存率、神经功能恢复情况和GCS评分来衡量预后。
高血压是最常见的危险因素,28例(70%)患者存在该因素。饮酒和吸烟也与自发性ICH显著相关。预后不良指标包括初始GCS评分低、血肿体积较大(>30 cm)、脑室内出血、脑积水和中线移位。60岁以上患者以及丘脑或脑干出血患者的死亡率更高。
在这一人群中,高血压仍然是自发性ICH的主要可改变危险因素。初始GCS评分、血肿体积和脑室内扩展是强有力的预后指标。对这些因素进行早期识别和针对性管理可能有助于改善预后。