Surgery for spontaneous supratentorial intracerebral haemorrhage.

RATIONALE

It is unknown whether surgery improves outcomes in people with spontaneous supratentorial intracerebral haemorrhage (ICH), and whether the effects of surgery differ according to the applied surgical technique. This review updated the methodology of a previous Cochrane review from 2008.

OBJECTIVES

To assess the benefits and harms of surgery plus standard medical management, compared to standard medical management alone, in people with spontaneous supratentorial ICH, and to assess whether the effect of surgery differs according to the surgical technique used.

SEARCH METHODS

We searched Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, and five other databases to 11 March 2025. We handsearched reference lists of included studies and relevant systematic reviews, forward-tracked relevant references, and contacted trialists for additional information on unpublished or ongoing studies.

ELIGIBILITY CRITERIA

We included randomised controlled trials (RCTs) of surgery (craniotomy with haematoma evacuation, minimally invasive surgery (MIS), or decompressive craniectomy) plus standard medical management in adults with a spontaneous supratentorial ICH, compared with standard medical management alone. We excluded studies of people with secondary causes of ICH (such as trauma, a macrovascular cause, or an intracranial tumour).

OUTCOMES

Critical outcomes were: good functional outcome at end of scheduled follow-up, and all-cause mortality at end of scheduled follow-up. Important outcomes were: 30-day case fatality and health-related quality of life (HRQoL) at end of scheduled follow-up.

RISK OF BIAS

We used the Cochrane RoB 1 tool.

SYNTHESIS METHODS

We conducted meta-analyses using random-effects models to calculate risk ratios (RR) with 95% confidence intervals (CI) for dichotomous data, and mean differences (MD) with 95% CI for continuous data. We summarised the certainty of the evidence using GRADE.

INCLUDED STUDIES

We included 24 RCTs (4597 participants). The studies were conducted in Europe, North and South America, Asia, Africa, and Australia, and were published between 1989 and 2024. Twenty-three studies examined surgery aimed at clot removal plus standard medical management versus standard medical management, of which six were included in the separate comparison of craniotomy with haematoma evacuation plus standard medical management versus standard medical management, and 14 in the comparison of MIS plus standard medical management versus standard medical management. One study examined decompressive craniectomy without haematoma evacuation plus standard medical management versus standard medical management.

SYNTHESIS OF RESULTS

Surgery aimed at clot removal plus standard medical management versus standard medical management alone Low-certainty evidence suggests that surgery aimed at clot removal may increase the chance of good functional outcome (RR 1.30, 95% CI 1.15 to 1.47; 18 studies, 4043 participants), and may reduce all-cause mortality (RR 0.79, 95% CI 0.71 to 0.88; 22 studies, 4278 participants) and 30-day case fatality (RR 0.74, 95% CI 0.60 to 0.90; 11 studies, 3179 participants). Surgery aimed at clot removal may have little to no effect on HRQoL, but the evidence is very uncertain (MD 0.03, 95% CI -0.05 to 0.11; 2 studies, 472 participants). Craniotomy with haematoma evacuation plus standard medical management versus standard medical management alone Craniotomy with haematoma evacuation may increase the chance of good functional outcome, but the evidence is very uncertain (RR 1.41, 95% CI 0.77 to 2.55; 6 studies, 853 participants). Craniotomy with haematoma evacuation likely reduces all-cause mortality (RR 0.80, 95% CI 0.67 to 0.96; 5 studies, 845 participants; moderate-certainty evidence), and may reduce 30-day case fatality (RR 0.68, 95% CI 0.46 to 1.00; 3 studies, 676 participants; low-certainty evidence), but the pooled CIs of 30-day case fatality included the possibility of no effect. Craniotomy with haematoma evacuation may result in little to no difference in HRQoL (MD 0.04, 95% CI -0.04 to 0.12; 1 study, 445 participants; low-certainty evidence). Minimally invasive surgery plus standard medical management versus standard medical management alone MIS may increase the chance of good functional outcome (RR 1.36, 95% CI 1.18 to 1.58; 10 studies, 2218 participants; low-certainty evidence), and probably reduces all-cause mortality (RR 0.71, 95% CI 0.60 to 0.84; 14 studies, 2401 participants; moderate-certainty evidence) and 30-day case fatality (RR 0.62, 95% CI 0.47 to 0.81; 7 studies, 1521 participants; moderate-certainty evidence). The evidence is very uncertain about HRQoL (MD -0.14, 95% CI -0.50 to 0.22; 1 study, 27 participants). Decompressive craniectomy plus standard medical management versus standard medical management alone Based on low-certainty evidence from one study, decompressive craniectomy may increase the chance of good functional outcome (RR 1.23, 95% CI 0.65 to 2.32; 182 participants), may reduce all-cause mortality (RR 0.74, 95% CI 0.45 to 1.19; 197 participants), and may result in little to no difference in HRQoL (MD 0.01, 95% CI -0.13 to 0.14), but the pooled CIs for these outcomes included the possibility of both benefit and harm. Decompressive craniectomy may also reduce 30-day case fatality, but the pooled CIs included the possibility of no effect (RR 0.43, 95% CI 0.19 to 1.00; 197 participants; low-certainty evidence).

AUTHORS' CONCLUSIONS: For people with spontaneous supratentorial ICH, surgery aimed at clot removal may increase the chance of achieving good functional outcome and may reduce all-cause mortality and 30-day case fatality compared to standard medical management. When the results are divided by neurosurgical approach for haematoma evacuation, craniotomy likely reduces all-cause mortality and may reduce 30-day case fatality, while its effect on good functional outcome is very uncertain. MIS may increase the chance of good functional outcome, and probably reduces all-cause mortality and 30-day case fatality. Although the effect estimates for all outcomes regarding decompressive craniectomy may suggest a beneficial effect, the pooled estimates were very imprecise and included the possibility of a harmful (good functional outcome and all-cause mortality) or no effect (30-day case fatality). Evidence on HRQoL was low or very low certainty, overall, and for each surgical technique. The certainty of the evidence was limited due to methodological shortcomings and the high risk of bias of most included studies, as well as imprecise pooled estimates and substantial heterogeneity in some analyses. More high-quality and adequately powered studies are needed to be more certain and to guide clinical practice.

FUNDING

This Cochrane review had no dedicated funding.

REGISTRATION

Protocol (2022) available via doi.org/10.1002/14651858.CD015387.