视黄醇缺乏对大鼠睾丸中全反式视黄醇醋酸酯代谢的影响。
The effect of retinol deficiency on the metabolism of all-trans-retinyl acetate in rat testes.
作者信息
Chaudhary L R, Nelson E C
出版信息
Int J Vitam Nutr Res. 1985;55(4):383-90.
Following intratesticular injection, the metabolism of all-trans-[11-3H] retinyl acetate was studied in rats fed a vitamin A-deficient diet supplemented either with retinyl palmitate (-A + RP) or retinoic acid (-A + RA). Analysis of testicular metabolites by HPLC at 6 h and 24 h demonstrated the hydrolysis of retinyl acetate to retinol, esterification of retinol to retinyl palmitate and the formation of trace amounts of retinoic acid and other metabolites in both groups of rats. Eight and nine metabolite peaks were present in the -A + RP and -A + RA groups, respectively. The HPLC profile was similar in both groups of rats but the amounts of metabolites differed.
在睾丸内注射后，研究了在喂食补充了棕榈酸视黄酯（-A + RP）或视黄酸（-A + RA）的维生素A缺乏饮食的大鼠中全反式-[11-³H]醋酸视黄酯的代谢情况。在6小时和24小时通过高效液相色谱法（HPLC）分析睾丸代谢物，结果表明两组大鼠中醋酸视黄酯均水解为视黄醇，视黄醇酯化为棕榈酸视黄酯，并形成了微量的视黄酸和其他代谢物。-A + RP组和 -A + RA组分别存在8个和9个代谢物峰。两组大鼠的HPLC图谱相似，但代谢物的量有所不同。
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