Hao Yang, Zheng Hanyu, Xiang Wenqiong, Chen Fangjun, Qiang Guangliang
Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, 100029, People's Republic of China.
China-Japan Friendship Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.
Int J Gen Med. 2025 Aug 19;18:4519-4533. doi: 10.2147/IJGM.S529705. eCollection 2025.
Epidemiological study has confirmed an association between hypothyroidism and pneumonia, but the causal relationship between the two remains unclear.
The National Health and Nutrition Examination Survey (NHANES) data were used to confirm the correlation between hypothyroidism and pneumonia. Mendelian randomization (MR) studies were conducted to explore the potential causal relationship. Co-expressed differential genes were used to identify potential mechanisms and potential drugs for pneumonia treatment, CCK8 and qPCR were used to detect the safety and efficacy of potential drugs. Molecular docking and Western blot assays were used to explore potential underlying mechanism of pneumonia treatment.
The NHANES and MR (Training set: OR=47.88, 95% CI: 8.432-271.8, P=1.3e-5; Test set: OR=1.849, 95% CI: 1.029-3.323, P=4.0e-5) analyses indicated that hypothyroidism may increase the risk of pneumonia. Moreover, increasing the usual walking pace was associated with a reduced risk of pneumonia, and sensitivity analysis indicated these results were robust. Hypothyroidism may increase the risk of pneumonia through the JAK-STAT signaling pathway. Garcinol was identified as a compound that attenuates lipopolysaccharide (LPS)-induced pneumonia via inhibiting the expression level of p-STAT1.
Hypothyroidism may elevate the risk of pneumonia, highlighting the need for preventive measures among hypothyroid patients, such as increasing walking pace. Additionally, garcinol shows potential therapeutic effects for pneumonia management.
流行病学研究已证实甲状腺功能减退与肺炎之间存在关联，但两者之间的因果关系仍不明确。
利用美国国家健康与营养检查调查（NHANES）数据来确认甲状腺功能减退与肺炎之间的相关性。进行孟德尔随机化（MR）研究以探索潜在的因果关系。使用共表达差异基因来确定肺炎治疗的潜在机制和潜在药物，采用CCK8和qPCR检测潜在药物的安全性和有效性。运用分子对接和蛋白质免疫印迹分析来探索肺炎治疗的潜在潜在机制。
NHANES和MR（训练集：OR = 47.88，95%CI：8.432 - 271.8，P = 1.3e - 5；测试集：OR = 1.849，95%CI：1.029 - 3.323，P = 4.0e - 5）分析表明，甲状腺功能减退可能会增加患肺炎的风险。此外，加快日常步行速度与降低肺炎风险相关，敏感性分析表明这些结果是可靠的。甲状腺功能减退可能通过JAK - STAT信号通路增加肺炎风险。藤黄酚被确定为一种通过抑制p - STAT1表达水平来减轻脂多糖（LPS）诱导的肺炎的化合物。
甲状腺功能减退可能会增加患肺炎的风险，这凸显了对甲状腺功能减退患者采取预防措施的必要性，例如加快步行速度。此外，藤黄酚对肺炎治疗显示出潜在的治疗效果。
