Henson Joseph, Yates Thomas, Bhattacharjee Atanu, Chudasama Yogini V, Davies Melanie J, Dempsey Paddy C, Goldney Jonathan, Khunti Kamlesh, Laukkanen Jari A, Razieh Cameron, Rowlands Alex V, Zaccardi Francesco
NIHR Leicester Biomedical Research Centre (Lifestyle), Leicester, UK; Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre (Lifestyle), Leicester, UK; Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.
Ann Epidemiol. 2024 Feb;90:21-27. doi: 10.1016/j.annepidem.2023.10.001. Epub 2024 Jan 4.
To estimate time spent in various cardiovascular disease (CVD) and cancer states, according to self-reported walking pace.
In total, 391,744 UK Biobank participants were included (median age = 57 years; 54.7% women). Data were collected 2006-2010, with follow-up collected in 2021. Usual walking pace was self-defined as slow, steady, average, or brisk. Multistate modeling determined the transition rate and mean sojourn time in and across three different states (healthy, CVD or cancer, and death) upon a time horizon of 10 years.
The mean sojourn time in the healthy state was longer, while that in the CVD or cancer state was shorter in individuals reporting an average or brisk walking pace (vs. slow). A 75-year-old woman reporting a brisk walking pace spent, on average, 8.4 years of the next 10 years in a healthy state; an additional 8.0 (95% CI: 7.3, 8.7) months longer than a 75-year-old woman reporting a slow walking pace. This corresponded to 4.3 (3.7, 4.9) fewer months living with CVD or cancer. Similar results were seen in men.
Adults reporting an average or brisk walking pace at baseline displayed a lower transition to disease development and a greater proportion of life lived without CVD or cancer.
Research was conducted using the UK Biobank resource under Application #33266. The UK Biobank resource can be accessed by researchers on application. Variables derived for this study have been returned to the UK Biobank for future applicants to request. No additional data are available.
根据自我报告的步行速度，估算在各种心血管疾病（CVD）和癌症状态下所花费的时间。
总共纳入了391,744名英国生物银行参与者（中位年龄 = 57岁；54.7%为女性）。数据于2006 - 2010年收集，并于2021年进行随访。通常步行速度被自我定义为慢、稳、平均或轻快。多状态建模确定了在10年时间范围内，在三种不同状态（健康、CVD或癌症、死亡）内及之间的转移率和平均停留时间。
报告平均或轻快步行速度的个体在健康状态下的平均停留时间更长，而在CVD或癌症状态下的平均停留时间更短（与慢步行速度者相比）。一名报告轻快步行速度的75岁女性，在接下来的10年中平均有8.4年处于健康状态；比一名报告慢步行速度的75岁女性多8.0（95%置信区间：7.3，8.7）个月。这相当于患CVD或癌症的时间减少了4.3（3.7，4.9）个月。男性也有类似结果。
基线时报告平均或轻快步行速度的成年人向疾病发展的转变较低，且无CVD或癌症的生活比例更高。
本研究使用了英国生物银行资源，申请编号为#33266。研究人员可通过申请访问英国生物银行资源。本研究衍生的变量已返回英国生物银行供未来申请者索取。无其他可用数据。
