Appiah Duke, Almosa Abdulkader, Heath Eli, De La Cruz Noah, Shabaneh Obadeh
Julia Jones Matthews School of Population and Public Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
College of Arts and Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Curr Oncol. 2025 Aug 8;32(8):447. doi: 10.3390/curroncol32080447.
Little is known about the manifestation of cardiovascular diseases (CVD) among individuals with ocular cancer (OC), a population for whom reports on sex-based differences in survival remain inconsistent. We evaluated the occurrence of CVD mortality after the diagnosis of OC in the United States. We used data from 11,460 adults diagnosed with OC from 2000 to 2021 who were ≥18 years and were enrolled in the Surveillance, Epidemiology, and End Results program. We used competing risk models to estimate hazard ratios (HR) and 95% confidence intervals (CI). About 55% of adults were male, with uveal melanoma being the most common OC (72.1%). During a median follow-up of 5.4 years, 4561 deaths occurred, with 15% attributable to CVD. In models adjusted for sociodemographic and clinico-pathophysiological factors, male adults had elevated risk for CVD mortality (HR: 1.54, 95%CI: 1.31-1.81). The sex difference in CVD mortality was more prominent for adults diagnosed with OC before 65 years of age (HR: 2.15; 95%CI: 1.48-3.11). These associations remained largely unchanged in propensity score analysis. In this study of adults with OC, CVD deaths were higher among young and middle-aged males. Implementation of optimal cardiovascular health interventions after diagnosis of OC, especially among men, holds promise in enhancing survival in this population.
关于眼癌（OC）患者中心血管疾病（CVD）的表现知之甚少，对于这一人群，关于生存性别差异的报告仍不一致。我们评估了美国眼癌诊断后心血管疾病死亡率的发生情况。我们使用了2000年至2021年期间11460名年龄≥18岁、被诊断为眼癌并纳入监测、流行病学和最终结果计划的成年人的数据。我们使用竞争风险模型来估计风险比（HR）和95%置信区间（CI）。约55%的成年人是男性，葡萄膜黑色素瘤是最常见的眼癌类型（72.1%）。在中位随访5.4年期间，发生了4561例死亡，其中15%归因于心血管疾病。在根据社会人口统计学和临床病理生理因素进行调整的模型中，成年男性心血管疾病死亡风险升高（HR：1.54，95%CI：1.31 - 1.81）。对于65岁之前被诊断为眼癌的成年人，心血管疾病死亡率的性别差异更为显著（HR：2.15；95%CI：1.48 - 3.11）。在倾向得分分析中，这些关联基本保持不变。在这项针对眼癌成年患者的研究中，年轻和中年男性的心血管疾病死亡人数更高。眼癌诊断后实施最佳心血管健康干预措施，尤其是在男性中，有望提高这一人群的生存率。
