Shiro Chiharu, Nishikawa Hiroki, Kong Xiangbo, Tomiyama Hiroyuki, Yamashita Shigeru
Graduate School of Science and Engineering, Ritsumeikan University, Kusatsu 525-8577, Japan.
WITZ Corporation, Nagoya 460-0004, Japan.
Biosensors (Basel). 2025 Aug 14;15(8):533. doi: 10.3390/bios15080533.
Micro Electrode Dot Array (MEDA) biochips have recently attracted considerable attention in the biochemical and medical industries. MEDA biochips manipulate micro droplets for biochemical experiments such as DNA analysis. Droplets on MEDA biochips are moved using the Electrowetting on Dielectric (EWOD) effect, but a portion of a droplet may remain on a cell after passing through, contaminating the cell. Other droplets cannot pass through a contaminated cell. In previous studies, contaminated cells were considered unavailable for droplet routing. As the number of contaminated cells increases, droplets may be prevented from moving to the desired position. Therefore, we propose a method for simultaneous routing of target functional and washing droplets based on a shape-dependent velocity model. In a simulation, the proposed method reduced the routing time by about 10% compared with an existing method.
微电极点阵列（MEDA）生物芯片最近在生化和医疗行业引起了相当大的关注。MEDA生物芯片操纵微滴进行诸如DNA分析等生化实验。MEDA生物芯片上的微滴利用介电电泳（EWOD）效应移动，但微滴通过后可能会有一部分残留在单元上，从而污染该单元。其他微滴无法通过被污染的单元。在先前的研究中，被污染的单元被认为无法用于微滴路由。随着被污染单元数量的增加，微滴可能会被阻止移动到期望的位置。因此，我们提出了一种基于形状依赖速度模型的目标功能微滴和清洗微滴同时路由的方法。在模拟中，与现有方法相比，该方法将路由时间减少了约10%。
