Yan Yuhao, Liu Yinuo, Zhang Xinwei, Zan Liting, Fang Xibi
Laboratory of Nutrition and Functional Food, College of Food Science and Engineering, Jilin University, Changchun 130062, China.
College of Animal Science, Jilin University, Changchun 130062, China.
Metabolites. 2025 Jul 29;15(8):505. doi: 10.3390/metabo15080505.
Cell proliferation plays a pivotal role in multiple physiological processes, including osteoporosis alleviation, wound healing, and immune enhancement. Numerous novel peptides with cell proliferation-promoting activity have been identified. These peptides exert their functions by modulating key cellular signaling pathways, thereby regulating diverse biological processes related to cell proliferation. This work summarizes peptides derived from animals and plants that stimulate cell proliferation, focusing on their amino acid composition, physicochemical properties, and preparation techniques. Furthermore, we highlight the major signaling pathways-such as the PI3K/Akt, MAPK/ERK, and Wnt/β-catenin pathways-that have been implicated in the mechanistic studies of food-derived peptides. Through the analysis and summary of previous studies, we observe a notable lack of in vivo animal models and clinical trials, indicating that these may represent promising directions for future research on food-derived bioactive peptides. Meanwhile, the potential safety concerns of proliferation-enhancing peptides-such as immunogenicity, appropriate dosage, and gastrointestinal stability-warrant greater attention. In summary, this review provides a comprehensive overview of the sources and mechanisms of cell proliferation-promoting peptides and addresses the challenges in industrializing bioactive peptide-based functional foods; therefore, further research in this area is encouraged.
细胞增殖在多种生理过程中发挥着关键作用，包括缓解骨质疏松、伤口愈合和增强免疫。已经鉴定出许多具有促进细胞增殖活性的新型肽。这些肽通过调节关键的细胞信号通路发挥其功能，从而调节与细胞增殖相关的各种生物学过程。这项工作总结了来自动物和植物的刺激细胞增殖的肽，重点关注它们的氨基酸组成、理化性质和制备技术。此外，我们强调了主要的信号通路，如PI3K/Akt、MAPK/ERK和Wnt/β-连环蛋白通路，这些通路已参与食物源肽的机制研究。通过对先前研究的分析和总结，我们发现体内动物模型和临床试验明显不足，这表明这些可能是未来食物源生物活性肽研究的有前景的方向。同时，增殖增强肽的潜在安全问题，如免疫原性、合适的剂量和胃肠道稳定性，值得更多关注。总之，本综述全面概述了促进细胞增殖肽的来源和机制，并解决了基于生物活性肽的功能性食品工业化中的挑战；因此，鼓励在该领域进行进一步研究。
