Vatansever Mehmet, Yaman Selçuk, Cimbek Ahmet, Sezgin Yılmaz, Yaman Serap Ozer
Department of Family Medicine, Kanuni Training and Research Hospital, University of Health Sciences, Trabzon 61080, Türkiye.
Department of Medical Biochemistry, Trabzon Kanuni Training and Research Hospital, University of Health Sciences, Trabzon 61080, Türkiye.
Metabolites. 2025 Aug 1;15(8):521. doi: 10.3390/metabo15080521.
Metabolic syndrome (MetS) is a complex clinical condition characterized by the coexistence of interrelated metabolic abnormalities that significantly increase the risk of cardiovascular diseases and type 2 diabetes mellitus. Endocan-an endothelial cell-specific molecule-is considered a biomarker of endothelial dysfunction and inflammation. This study aimed to evaluate the relationship between serum endocan levels and the severity of MetS, assessed using the MetS-Z score. This study included 120 patients with MetS and 50 healthy controls. MetS was diagnosed according to the NCEP-ATP III criteria. MetS-Z scores were calculated using the MetS Severity Calculator. Serum levels of endocan, sICAM-1, and sVCAM-1 were measured using the ELISA method. Serum levels of endocan, sICAM-1, and sVCAM-1 were significantly higher in the MetS group compared to the control group (all < 0.001). When the MetS group was divided into tertiles based on MetS-Z scores, stepwise and statistically significant increases were observed in the levels of endocan and other endothelial markers from the lowest to highest tertile ( < 0.0001). Correlation analysis revealed a strong positive association between the MetS-Z score and serum endocan levels (r = 0.584, < 0.0001). ROC curve analysis showed that endocan has high diagnostic accuracy for identifying MetS (AUC = 0.967, = 0.0001), with a cutoff value of >88.0 ng/L. Circulating levels of endocan were significantly increased in MetS and were associated with the severity of MetS, suggesting that endocan may play a role in the cellular response to endothelial dysfunction-related injury in patients with MetS.
代谢综合征（MetS）是一种复杂的临床病症，其特征是相互关联的代谢异常并存，这会显著增加心血管疾病和2型糖尿病的风险。内脂素——一种内皮细胞特异性分子——被认为是内皮功能障碍和炎症的生物标志物。本研究旨在评估血清内脂素水平与使用MetS-Z评分评估的MetS严重程度之间的关系。本研究纳入了120例MetS患者和50名健康对照者。根据NCEP-ATP III标准诊断MetS。使用MetS严重程度计算器计算MetS-Z评分。采用酶联免疫吸附测定（ELISA）法测定血清内脂素、可溶性细胞间黏附分子-1（sICAM-1）和可溶性血管细胞黏附分子-1（sVCAM-1）水平。与对照组相比，MetS组血清内脂素、sICAM-1和sVCAM-1水平显著更高（均P<0.001）。当根据MetS-Z评分将MetS组分为三个三分位数时，从最低到最高三分位数，内脂素和其他内皮标志物水平呈逐步且具有统计学意义的升高（P<0.0001）。相关性分析显示MetS-Z评分与血清内脂素水平之间存在强正相关（r = 0.584，P<0.0001）。ROC曲线分析表明，内脂素对识别MetS具有较高的诊断准确性（曲线下面积[AUC]=0.967，P = 0.0001），临界值>88.0 ng/L。MetS患者循环内脂素水平显著升高，并与MetS严重程度相关，提示内脂素可能在MetS患者对内皮功能障碍相关损伤的细胞反应中起作用。
