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餐后血脂异常时循环血中内卡蛋白水平升高与内皮细胞及炎症因子水平增加有关。

Elevated Circulating Endocan Levels Are Associated with Increased Levels of Endothelial and Inflammation Factors in Postprandial Lipemia.

作者信息

Ozer Yaman Serap, Balaban Yucesan Fulya, Orem Cihan, Vanizor Kural Birgul, Orem Asım

机构信息

Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.

Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.

出版信息

J Clin Med. 2023 Feb 6;12(4):1267. doi: 10.3390/jcm12041267.

DOI:10.3390/jcm12041267
PMID:36835804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9966245/
Abstract

BACKGROUND

Postprandial lipemia (PPL) causes endothelial dysfunction by causing endothelial damage to lipoproteins that remain rich in triglycerides. Endocan is a proteoglycan with increased tissue expression, endothelial activation, and neovascularization. The aim of the study was to examine circulating endocan levels in PPL subjects by considering the degree of PPL response according to a high-fat test meal. The other aim was to determine the association between endocan levels and endothelial and inflammatory factors.

METHOD

Fifty-four hyperlipidemic subjects and 28 normolipidemic subjects consumed the high-fat meal. Endocan, sICAM-1, sVCAM-1, and VEGFA as endothelial factors and IL-6 and LFA-1α as inflammatory factors were evaluated.

RESULTS

Fasting serum endocan, VEGFA, sICAM-1, sVCAM-1 IL-6, and LFA-1α levels were increased in the PPL group compared to the control group. The PPL group was divided into tertiles based on mean AUC levels. Endocan levels in tertile 3 were at the highest and were increased significantly compared to tertiles 1 and 2. AUC and endocan levels were positively correlated with other endothelial and inflammation factors. ROC analysis showed endocan levels to be one of the highest values.

CONCLUSIONS

Circulating endocan is seen at significantly higher levels and independently associated with endothelial and inflammatory factors in postprandial lipemia and dyslipidemia.

摘要

背景

餐后血脂异常（PPL）通过对富含甘油三酯的脂蛋白造成内皮损伤而导致内皮功能障碍。内脂素是一种蛋白聚糖，其组织表达、内皮激活和新生血管形成均增加。本研究的目的是通过根据高脂试验餐评估PPL反应程度来检测PPL受试者的循环内脂素水平。另一个目的是确定内脂素水平与内皮及炎症因子之间的关联。

方法

54名高脂血症受试者和28名血脂正常受试者食用了高脂餐。评估了作为内皮因子的内脂素、可溶性细胞间黏附分子-1（sICAM-1）、可溶性血管细胞黏附分子-1（sVCAM-1）和血管内皮生长因子A（VEGFA），以及作为炎症因子的白细胞介素-6（IL-6）和淋巴细胞功能相关抗原-1α（LFA-1α）。

结果

与对照组相比，PPL组的空腹血清内脂素、VEGFA、sICAM-1、sVCAM-1、IL-6和LFA-1α水平升高。根据平均曲线下面积（AUC）水平将PPL组分为三分位数。三分位数3中的内脂素水平最高，与三分位数1和2相比显著升高。AUC和内脂素水平与其他内皮和炎症因子呈正相关。ROC分析显示内脂素水平是最高值之一。

结论

在餐后血脂异常和血脂异常中，循环内脂素水平显著升高，且与内皮和炎症因子独立相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f97/9966245/2a5b7c141a7c/jcm-12-01267-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f97/9966245/30e0396f5380/jcm-12-01267-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f97/9966245/11c997c6b5f7/jcm-12-01267-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f97/9966245/2a5b7c141a7c/jcm-12-01267-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f97/9966245/30e0396f5380/jcm-12-01267-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f97/9966245/11c997c6b5f7/jcm-12-01267-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f97/9966245/2a5b7c141a7c/jcm-12-01267-g003.jpg

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J Clin Med. 2020 Dec 18;9(12):4086. doi: 10.3390/jcm9124086.
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