Institute of Dermatology, Guangzhou Medical University, Guangzhou, China.
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China.
Arch Dermatol Res. 2024 Jun 15;316(7):403. doi: 10.1007/s00403-024-03069-y.
The association between psoriasis and hyperthyroidism/hypothyroidism remains inconclusive, with conflicting findings in prior studies.
This study employs Mendelian randomization methods to assess the potential relationship.
Given the inability to accurately observe the link between psoriasis and thyroid dysfunction, we prioritized utilizing known genetic variants to investigate the potential impacts of the disease.We analyzed data from genome-wide association studies (GWASs), FinnGen, and UK Biobank to extract information on psoriasis, hyperthyroidism, and hypothyroidism. Three MR approaches (MR Egger, weighted median, and inverse variance weighted) were used to scrutinize the causal link.
Our analysis revealed no correlation between psoriasis and hyperthyroidism/hypothyroidism. However, vulgar psoriasis and guttate psoriasis were associated with hypothyroidism/myxedema (IVW odds ratio (OR) = 1.00, 95% confidence interval (CI) = 1.00-1.00, P = 2.53E-03), and Graves' disease (IVW OR = 0.86, 95% CI = 0.72-1.01, P = 4.75E-02).In a subsequent analysis, we observed that hypothyroidism with mucinous edema showed no correlation with Graves' disease in the opposite(P = 9.33E-01).
This MR analysis suggests no association between psoriasis and thyroid dysfunction, but highlights associations of vulgar/guttate psoriasis with hypothyroidism/myxedema and Graves' disease. In clinical practice, diagnosing guttate psoriasis requires vigilance for associated risks from hypothyroidism and Graves' disease. For patients with both vulgar psoriasis and hypothyroidism, careful monitoring for mucinous edema is crucial, as it may signal a hypothyroid crisis.
银屑病与甲状腺功能亢进症/甲状腺功能减退症之间的关联仍不确定，先前的研究结果存在矛盾。
本研究采用孟德尔随机化方法来评估这种潜在的关联。
由于无法准确观察银屑病与甲状腺功能障碍之间的联系，我们优先利用已知的遗传变异来研究疾病的潜在影响。我们分析了来自全基因组关联研究（GWAS）、芬兰人群（FinnGen）和英国生物库（UK Biobank）的数据，以提取有关银屑病、甲状腺功能亢进症和甲状腺功能减退症的信息。我们使用三种 MR 方法（MR Egger、加权中位数和逆方差加权）来仔细研究因果关系。
我们的分析表明银屑病与甲状腺功能亢进症/甲状腺功能减退症之间没有关联。然而，寻常型银屑病和点滴状银屑病与甲状腺功能减退症/黏液性水肿（IVW 比值比（OR）= 1.00，95%置信区间（CI）= 1.00-1.00，P= 2.53E-03）和格雷夫斯病（IVW OR= 0.86，95% CI= 0.72-1.01，P= 4.75E-02）相关。在随后的分析中，我们观察到黏液性水肿性甲状腺功能减退症与格雷夫斯病之间没有关联（P= 9.33E-01）。
这项 MR 分析表明银屑病与甲状腺功能障碍之间没有关联，但强调了寻常型/点滴状银屑病与甲状腺功能减退症/黏液性水肿和格雷夫斯病之间的关联。在临床实践中，诊断点滴状银屑病需要警惕与甲状腺功能减退症和格雷夫斯病相关的风险。对于同时患有寻常型银屑病和甲状腺功能减退症的患者，需要密切监测黏液性水肿，因为这可能提示甲状腺危象。
