Glavina Ana, Špiljak Bruno, Glavina Durdov Merica, Milić Ivan, Perko Marija Ana, Mešin Delić Dora, Lugović-Mihić Liborija
Department of Dental Medicine, University Hospital of Split, 21000 Split, Croatia.
Department of Oral Medicine, Study of Dental Medicine, School of Medicine, University of Split, 21000 Split, Croatia.
Diseases. 2025 Aug 3;13(8):243. doi: 10.3390/diseases13080243.
Secukinumab (SEC) is a recombinant, fully human monoclonal antibody that is selective for interleukin-17A (IL-17A). SEC may increase the risk of developing infections such as oral herpes and oral candidiasis. The aim of this case report and literature review was to describe chronic hyperplastic candidiasis (CHC) in a patient with psoriasis (PsO) and psoriatic arthritis (PsA) treated with SEC. CHC is a rare and atypical clinical entity. A definitive diagnosis requires biopsy of the oral mucosa for histopathological diagnosis (PHD). The differential diagnosis includes hairy tongue, hairy leukoplakia, oral lichen planus (OLP), oral lichenoid reaction (OLR), leukoplakia, frictional keratosis, morsication, oral psoriasis, syphilis, and oral lesions associated with coronavirus disease (COVID-19). In addition to the usual factors (xerostomia, smoking, antibiotics, vitamin deficiency, immunosuppression, comorbidities), the new biological therapies/immunotherapies are a predisposing factor for oral candidiasis. The therapeutic approach must be multidisciplinary and in consultation with a clinical immunologist. Dentists and specialists (oral medicine, dermatologists, rheumatologists) must be familiar with the oral adverse events of the new biological therapies. Simultaneous monitoring of patients by clinical immunology and oral medicine specialists is crucial for timely diagnosis and therapeutic intervention to avoid possible adverse events and improve quality of life (QoL).
司库奇尤单抗（SEC）是一种重组的全人单克隆抗体，对白细胞介素-17A（IL-17A）具有选择性。SEC可能会增加发生口腔疱疹和口腔念珠菌病等感染的风险。本病例报告及文献综述的目的是描述一名接受SEC治疗的银屑病（PsO）和银屑病关节炎（PsA）患者的慢性增生性念珠菌病（CHC）。CHC是一种罕见的非典型临床实体。明确诊断需要对口腔黏膜进行活检以进行组织病理学诊断（PHD）。鉴别诊断包括毛舌、毛状白斑、口腔扁平苔藓（OLP）、口腔苔藓样反应（OLR）、白斑、摩擦性角化病、咬颊、口腔银屑病、梅毒以及与冠状病毒病（COVID-19）相关的口腔病变。除了常见因素（口干、吸烟、抗生素、维生素缺乏、免疫抑制、合并症）外，新型生物疗法/免疫疗法也是口腔念珠菌病的诱发因素。治疗方法必须是多学科的，并咨询临床免疫学家。牙医和专科医生（口腔医学、皮肤科医生、风湿病学家）必须熟悉新型生物疗法的口腔不良事件。临床免疫学和口腔医学专家同时对患者进行监测对于及时诊断和治疗干预至关重要，以避免可能的不良事件并提高生活质量（QoL）。
