Hauer Lukas, Moztarzadeh Omid, Baghalipour Nasimeh, Gencur Jiri
Department of Stomatology, University Hospital Pilsen, Faculty of Medicine in Pilsen, Charles University, Pilsen, 32300, Czech Republic.
Department of Anatomy, Faculty of Medicine in Pilsen, Charles University, Pilsen, 32300, Czech Republic.
Psoriasis (Auckl). 2024 Sep 23;14:115-120. doi: 10.2147/PTT.S490982. eCollection 2024.
The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition known as medication-related osteonecrosis of the jaw (MRONJ). In this article, we present a unique case of MRONJ in a patient with no history of antiresorptive or antiangiogenic drug use, who was instead taking the anti-interleukin 17-A (Secukinumab) medication for severe psoriasis. This association has not been previously reported in the literature.
抗血管生成和抗吸收药物的使用，尤其是在癌症或骨质疏松症患者中，在拔牙、外伤后或自发发生时可导致颌骨坏死——一种称为药物相关性颌骨坏死（MRONJ）的病症。在本文中，我们报告了一例独特的MRONJ病例，该患者无抗吸收或抗血管生成药物使用史，而是正在服用抗白细胞介素17 - A（司库奇尤单抗）药物治疗严重银屑病。这种关联此前尚未见文献报道。
