Khoury Tawfik, Sbeit Wisam, Lisotti Andrea, Napoléon Bertrand
Department of Gastroenterology, Galilee Medical Center, Nahariya 22100, Israel.
Faculty of Medicine in the Galilee, Bar-Ilan University, Safed 5290002, Israel.
Diseases. 2025 Aug 21;13(8):273. doi: 10.3390/diseases13080273.
BACKGROUND/OBJECTIVES: Malignant biliary diseases still represent a therapeutic challenge given its poor prognosis, and limited response to the available curative treatments. Recently, endobiliary radiofrequency ablation (RFA) has been increasingly reported as an adjunct therapeutic option for biliary diseases, especially malignant biliary obstruction (MBO), due to potentially improving survival and stent patency.
Herein, we provide a comprehensive review article discussing the indication, procedural details, safety, and comparative efficacy of endobiliary RFA to aid in providing an in-depth understanding of the clinical indications and future implications of this specific option.
Overall, endobiliary RFA is technically feasible, being associated with a high safety profile, significantly improving biliary stent patency, and having a potential benefit in extending the survival of patients with MBO who were treated with endobiliary RFA combined with biliary stenting vs. stenting alone. Moreover, it has a promising role in the treatment of intraductal extension of ampullary tumors.
Endobiliary RFA had a beneficial therapeutic effect in biliary strictures, with potential impact on patients outcome and survival.
背景/目的：恶性胆道疾病因其预后较差且对现有根治性治疗的反应有限，仍然是一个治疗挑战。最近，越来越多的报道称，由于可能提高生存率和支架通畅率，胆管内射频消融（RFA）已成为胆道疾病，尤其是恶性胆管梗阻（MBO）的一种辅助治疗选择。
在此，我们提供一篇全面的综述文章，讨论胆管内RFA的适应证、操作细节、安全性和比较疗效，以帮助深入了解这一特定治疗选择的临床适应证和未来意义。
总体而言，胆管内RFA在技术上是可行的，具有较高的安全性，能显著提高胆管支架的通畅率，对于接受胆管内RFA联合胆管支架置入术而非单纯支架置入术治疗的MBO患者，在延长生存期方面具有潜在益处。此外，它在壶腹肿瘤的导管内扩展治疗中具有广阔前景。
胆管内RFA对胆道狭窄具有有益的治疗效果，对患者的预后和生存可能产生影响。
