在美国，膳食纤维摄入量与全因死亡率呈负相关，但与癌症和心血管疾病死亡率无关。

Dietary Fiber Intake Was Inversely Associated with All-Cause Mortality but Not with Cancer and Cardiovascular Disease Mortalities in the US.

作者信息

Akbar Zoha, Fituri Sundus, Shi Zumin, Ganji Vijay

机构信息

Department of Nutrition Sciences, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Nutrition and Dietetics Program, School of Health and Human Sciences, Indiana University Indianapolis, Indianapolis, IN 46202, USA.

出版信息

Diseases. 2025 Aug 21;13(8):272. doi: 10.3390/diseases13080272.

DOI:10.3390/diseases13080272

PMID:40863246

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12385747/

Abstract

BACKGROUND

Evidence linking dietary fiber intake with cancer risk and mortality is equivocal.

OBJECTIVE

We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US adults ≥ 20 years.

METHODS

Data from the National Health and Nutrition Examination Surveys (NHANES) from 2003 to 2016 were used. Seven two-year cycles were concatenated into one analytic data file, NHANES 2003-2016 ( = 25,868; age ≥ 20 years). Dietary fiber intakes were collected from one 24-h dietary recall. Fiber intakes were categorized into quartiles. Mortality information was obtained from data linkage. To determine mortality, subjects were followed up for 6.4 years. Association between dietary fiber and mortality from all causes, cancer, and CVD was determined with multivariable-adjusted Cox proportional hazards models. Multivariate-adjusted Cox proportional hazard regression was used to generate mortality survival rates.

RESULTS

During the follow-up period, out of 2520 deaths, 561 and 511 deaths were from cancer and CVD, respectively. Dietary fiber intake was inversely associated with all-cause mortality [RR (95% CI), 0.67 (0.56-0.80); ≤ 0.001]. No relationship was observed between fiber intake and cancer mortality [RR (95% CI), 0.8 (0.55-1.17); = 0.51] and CVD mortality [RR (95% CI), 0.84 (0.53-1.33); = 0.67].

CONCLUSIONS

In the US population, dietary fiber intake was associated with decreased all-cause mortality, but not with cancer and CVD mortality.

摘要

背景

膳食纤维摄入量与癌症风险及死亡率之间的证据并不明确。

目的

我们调查了美国20岁及以上成年人膳食纤维摄入量与全因死亡率、癌症死亡率和心血管疾病（CVD）死亡率之间的关系。

方法

使用了2003年至2016年国家健康与营养检查调查（NHANES）的数据。将七个两年周期的数据合并到一个分析数据文件中，即NHANES 2003 - 2016（n = 25868；年龄≥20岁）。通过一次24小时饮食回顾收集膳食纤维摄入量。将纤维摄入量分为四分位数。死亡率信息通过数据链接获得。为确定死亡率，对受试者进行了6.4年的随访。使用多变量调整的Cox比例风险模型确定膳食纤维与全因、癌症和CVD死亡率之间的关联。使用多变量调整的Cox比例风险回归生成死亡率生存率。

结果

在随访期间，2520例死亡中，分别有561例和511例死于癌症和CVD。膳食纤维摄入量与全因死亡率呈负相关[RR（95%CI），0.67（0.56 - 0.80）；P≤0.001]。未观察到纤维摄入量与癌症死亡率[RR（95%CI），0.8（0.55 - 1.17）；P = 0.51]和CVD死亡率[RR（95%CI），0.84（0.53 - 1.33）；P = 0.67]之间的关系。