Sehgal Sakshi, Pollard Elinita, Charles Toscha, Thomas Marquetta, Vernon Marlo, Sharma Gyanendra, Ray Chadburn
Medical College of Georgia, Augusta University, 1120 15th St, Augusta, GA 30912, USA.
Georgia Prevention Institute, Augusta University, 1499 Walton Way, Augusta, GA 30901, USA.
J Cardiovasc Dev Dis. 2025 Aug 13;12(8):307. doi: 10.3390/jcdd12080307.
Perinatal cardiovascular disease accounts for nearly one-third of pregnancy-related deaths, with nearly 70% of these deaths preventable with appropriate cardio-obstetric care. The objective is to assess whether socioeconomic disadvantage, utilizing area deprivation index national and state rankings as a proxy, contributes to a higher risk of CV disease during the perinatal period. A single-site retrospective cohort study of 388 electronic health records patients seen at a novel cardio-obstetrics program between June 2022 and May 2024 was conducted. The main exposure was ADI state rankings, and the primary outcome of interest was diagnosis of perinatal CV disease, with secondary measures including preeclampsia, hypertension, and peripartum cardiomyopathy. Multivariable logistic regression models were utilized to examine the association between ADI and perinatal CV disease. National ADI ranking was associated with an increased odds of developing preeclampsia (OR: 2.56, 95% CI: 1.12-5.89) and HTN (OR: 2.37, 95% CI: 1.19-4.72). Socioeconomic disadvantage during the perinatal period is associated with a statistically significant risk of CV disease, including preeclampsia, hypertension, and peripartum cardiomyopathy, as well as any CV diagnosis in general.
围产期心血管疾病占与妊娠相关死亡人数的近三分之一，其中近70%的死亡可通过适当的心脏产科护理预防。目的是评估利用国家和州层面的地区贫困指数排名作为社会经济劣势指标，是否会增加围产期心血管疾病的风险。对2022年6月至2024年5月期间在一个新型心脏产科项目中就诊的388例电子健康记录患者进行了单中心回顾性队列研究。主要暴露因素是地区贫困指数州排名，感兴趣的主要结局是围产期心血管疾病的诊断，次要指标包括子痫前期、高血压和围产期心肌病。采用多变量逻辑回归模型来检验地区贫困指数与围产期心血管疾病之间的关联。国家地区贫困指数排名与子痫前期（比值比：2.56，95%置信区间：1.12 - 5.89）和高血压（比值比：2.37，95%置信区间：1.19 - 4.72）发病几率增加相关。围产期的社会经济劣势与心血管疾病的统计学显著风险相关，包括子痫前期、高血压和围产期心肌病，以及总体上的任何心血管疾病诊断。
