Norões Terentia Batista Sa, Jorge Antonio Rafael Coelho, Monteiro Helena Serra Azul, Vieira Ricardo Parente Garcia, Macêdo Breno De Sá Barreto
Department of Medicine, Centro Universitário Doutor Leão Sampaio (UNILEÃO), Maria Letícia Leite Pereira Ave., Lagoa Seca-Cidade Universitária, Juazeiro do Norte 63040-405, CE, Brazil.
Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, Fortaleza 60430-275, CE, Brazil.
Toxins (Basel). 2025 Jul 24;17(8):363. doi: 10.3390/toxins17080363.
The snakes from the genus are responsible for most of the ophidic accidents in Brazil, and represents one of these species. Envenomation by these snakes results in systemic effects and is often associated with early mortality following snakebite incidents. The present study investigates the pharmacological properties of venom (VBA), focusing specifically on its impact on renal blood flow. Following the renal perfusion procedure, kidney tissues were processed for histopathological examination. Statistical analysis of all evaluated parameters was conducted using ANOVA and Student's -test, with significance set at < 0.005. Administration of VBA resulted in a marked reduction in both perfusion pressure and renal vascular resistance. In contrast, there was a significant elevation in urinary output and glomerular filtration rate. Histological changes observed in the perfused kidneys were mild. The involvement of nitric oxide in the pressor effects of venom was not investigated in renal perfusion systems or in in vivo models. Treatment with VBA led to elevated nitrite levels in the bloodstream of the experimental animals. This effect was completely inhibited following pharmacological blockade with L-NAME. Based on these findings, we conclude that VBA alters renal function and promotes increased nitric oxide production.
该属的蛇类是巴西大多数蛇伤事故的罪魁祸首，[具体蛇种名称]就是其中之一。这些蛇的毒液注入会导致全身效应，并且在蛇咬事件后常与早期死亡相关。本研究调查了[具体蛇种名称]毒液（VBA）的药理特性，特别关注其对肾血流量的影响。在进行肾灌注程序后，对肾脏组织进行组织病理学检查。使用方差分析和学生 t 检验对所有评估参数进行统计分析，显著性设定为 P < 0.005。给予 VBA 导致灌注压力和肾血管阻力显著降低。相反，尿量和肾小球滤过率显著升高。在灌注的肾脏中观察到的组织学变化轻微。在肾灌注系统或体内模型中未研究一氧化氮在[具体蛇种名称]毒液升压作用中的作用。用 VBA 治疗导致实验动物血液中亚硝酸盐水平升高。在用 L - NAME 进行药理阻断后，这种效应被完全抑制。基于这些发现，我们得出结论，VBA 会改变肾功能并促进一氧化氮生成增加。
