Zander B, Hörchner F
MMW Munch Med Wochenschr. 1977 Aug 5;119(31):1015-8.
The behavior of the IFT serum titer in 80 guinea-pigs, experimentally infected with Trichinella spiralis, was tested before and after treatment with mebendazole for 6 months. For 14 consecutive days each animal was drenched with 40 mg mebendazole/kg bw on the 25th, 35th and 45th day after infection. After the 2 weeks therapy, living trichinella larvae were not found in any of the 3 treated groups of guinea-pigs. On the other hand even after 6 months viable larvae were found in the muscular tissue of the control animals. Within the first two months p.i. the titers were rising equally in both treated and untreated animals. Only then did the titer in the treated animals decrease markedly, whereas it fell gradually in the controls. After 6 months both groups were negative in the IFT.
对80只经实验感染旋毛虫的豚鼠，在接受甲苯达唑治疗6个月前后检测其IFT血清滴度。在感染后第25、35和45天，每只动物连续14天每天灌服40mg甲苯达唑/千克体重。经过2周治疗后，3组接受治疗的豚鼠中均未发现活的旋毛虫幼虫。另一方面，即使在6个月后，仍在对照动物的肌肉组织中发现了活幼虫。感染后的头两个月内，治疗组和未治疗组动物的滴度均同等上升。只有在那时，治疗组动物的滴度才显著下降，而对照组则逐渐下降。6个月后，两组的IFT检测均为阴性。
