Fernando S S, Deham D A
J Parasitol. 1976 Dec;62(6):874-6.
Oral administration of either Mebendazole or Fenbendazole at 50 mg/kg body weight was effective in killing a 7-hr Trichinella spiralis infection in mice. Adult worms, 72 hr postingection, were unaffected by the same dose of Fenbendazole, while Mebendazole showed partial activity. Both Mebendazole and Fenbendazole were active against developing muscle larvae. Mebendazole was effective against encysted muscle larvae while 50 mg of Fenbendazole per kg per day for 7 days from 28 days postinfection failed to have any effect on this stage of the life-cycle.
以50毫克/千克体重口服甲苯咪唑或芬苯达唑可有效杀死感染小鼠7小时的旋毛虫。感染72小时后的成虫不受相同剂量芬苯达唑的影响，而甲苯咪唑表现出部分活性。甲苯咪唑和芬苯达唑对发育中的肌幼虫均有活性。甲苯咪唑对包囊化肌幼虫有效，而感染后28天起每天每千克给予50毫克芬苯达唑，连续7天，对生命周期的这一阶段没有任何影响。
