Walash M I, Rizk M S, el-Brashy A
J Assoc Off Anal Chem. 1985 Nov-Dec;68(6):1209-12.
Titrimetric and spectrophotometric titration methods are described for the quantitative determination of acetylenic hypnotics ethchlorvynol, ethinamate, and meparfynol carbamate as pure substances and in dosage forms. The methods involve the use of different brominating agents. A known excess of the reagent is added and, after the specified time, the residual reagent is determined iodometrically. These procedures permit semimicro determination (1-20 mg) of the drug. Recoveries ranged from 98.48 +/- 0.76 to 102.74 +/- 2.60%. The procedures have been successfully applied to pharmaceutical dosage forms; the results agree well with those for compendial methods.
本文描述了滴定法和分光光度滴定法，用于定量测定炔属催眠药炔氯维诺、炔己蚁胺和甲丙氨酯，这些药物以纯物质形式和剂型存在。这些方法涉及使用不同的溴化剂。加入已知过量的试剂，在规定时间后，用碘量法测定残留试剂。这些程序允许对药物进行半微量测定（1-20毫克）。回收率范围为98.48±0.76%至102.74±2.60%。这些程序已成功应用于药物剂型；结果与药典方法的结果非常吻合。
