Rizk M S, Walash M I, El-Brashy A
J Assoc Off Anal Chem. 1980 Jan;63(1):88-90.
A colorimetric method is described for the determination of certain mono-substituted acetylenic hypnotic drugs--ethinamate, methyl pentnol carbamate, and ethchlorvynol. Silver acetylide is formed and extracted into isobutyl methyl ketone. After acidification, an equivalent amount of silver ions is liberated which is assayed colorimetrically as silver dithizonate (lambda mx. 472 nm). About 10--50 microgram compound could be assayed with good accuracy. The procedure is reproducible and precise (standard deviation 1.5--2.19%). The procedure was successfully applied to different pharmaceutical dosage forms.
描述了一种比色法，用于测定某些单取代炔属催眠药物——炔己蚁胺、甲基戊炔醇氨基甲酸酯和炔氯维醇。乙炔银形成后被萃取到异丁基甲基酮中。酸化后，释放出等量的银离子，以双硫腙银（最大吸收波长472nm）进行比色测定。约10 - 50微克的化合物能够被准确测定。该方法具有可重复性且精确（标准偏差为1.5 - 2.19%）。该方法已成功应用于不同的药物剂型。
