Malisz Klaudia, Świeczko-Żurek Beata, Karczewski Jakub, Mirowska Aleksandra, Pałubicka Anna
Department of Biomaterials Technology, Faculty of Mechanical Engineering and Ship Technology, Gdansk University of Technology, Gabriela Narutowicza 11/12, 80-229, Gdansk, Poland.
Institute of Materials Sciences and Nanotechnology, Faculty of Applied Physics and Mathematics, Gdańsk University of Technology, Gabriela Narutowicza 11/12, 80-229, Gdansk, Poland.
J Mech Behav Biomed Mater. 2025 Dec;172:107172. doi: 10.1016/j.jmbbm.2025.107172. Epub 2025 Aug 20.
The aim of the work is to compare the properties of nanohydroxyapatite coatings containing antibiotic - gentamicin or silver nanoparticles. The coatings were obtained using the electrophoretic deposition method (EDP). The additives were introduced by the immersion method. Evaluation of the coating was performed by using a Scanning Electron Microscope (SEM), Energy Dispersive X-ray Spectrometer (EDX), and a drop shape analyzer. Antibacterial properties were examined by assessing the surface after incubation in a bacterial solution for 30 days. The corrosion properties of the materials were also assessed. Silver nanoparticles and the antibiotic were successfully incorporated into the nanohydroxyapatite coating. The wettability test shows the hydrophilic behavior of the coatings that contains an antibiotic. Furthermore, the average contact angle (CA) value for nanohydroxyapatite doped with silver nanoparticles increased to 120°. The highest surface roughness was observed for the coating containing silver. All nanohydroxapatite modifications improved the corrosion resistance of the titanium alloy, but the best results were obtained by nanohydroxapatite with AgNPs, where the Icorr parameter was 15.5 ± 3.9 μA/cm, Ecorr showed the most positive value of 25.6 ± 1.7 mV, and Rpol was 8.1 ± 0.2 kΩ cm. For comparison, the corresponding values for the nHAp coating are: 41.7 ± 1.9 μA/cm, -56.1 ± 1.6 mV, 3.6 ± 0.4 kΩ cm. It was found that both the coating with added AgNPs and the one with a higher concentration of gentamicin exhibited antibacterial properties. It can be stated that the silver-containing coating shows greater potential for combating perioperative infections due to the combination of good corrosion resistance and broad-spectrum antibacterial properties.
这项工作的目的是比较含有抗生素庆大霉素或银纳米颗粒的纳米羟基磷灰石涂层的性能。这些涂层是采用电泳沉积法（EDP）制备的。添加剂通过浸泡法引入。使用扫描电子显微镜（SEM）、能量色散X射线光谱仪（EDX）和滴形分析仪对涂层进行评估。通过在细菌溶液中孵育30天后评估表面来检测抗菌性能。还评估了材料的腐蚀性能。银纳米颗粒和抗生素成功地掺入到纳米羟基磷灰石涂层中。润湿性测试表明含抗生素的涂层具有亲水性。此外，掺杂银纳米颗粒的纳米羟基磷灰石的平均接触角（CA）值增加到了120°。含银涂层的表面粗糙度最高。所有纳米羟基磷灰石改性都提高了钛合金的耐腐蚀性，但含AgNPs的纳米羟基磷灰石取得了最佳结果，其Icorr参数为15.5±3.9μA/cm，Ecorr显示最正值为25.6±1.7mV，Rpol为8.1±0.2kΩ·cm。相比之下，nHAp涂层的相应值为：41.7±1.9μA/cm，-56.1±1.6mV，3.6±0.4kΩ·cm。发现添加AgNPs的涂层和庆大霉素浓度较高的涂层都具有抗菌性能。可以说，含银涂层由于具有良好的耐腐蚀性和广谱抗菌性能的结合，在对抗围手术期感染方面显示出更大的潜力。
