Rogers R C, Hermann G E
J Auton Nerv Syst. 1985 Dec;14(4):351-62. doi: 10.1016/0165-1838(85)90081-5.
Electrophysiological studies were performed to determine whether neurons of the nucleus of the solitary tract (NST) which receive sensory input from the stomach via vagal afferents are activated by microstimulation of the medial parvocellular division of the paraventricular nucleus of the hypothalamus (PVHmp). We found that 37% of the NST neurons orthodromically activated by gastric vagal nerve stimulation are also orthodromically excited by PVHmp microstimulation. Not only do these NST neurons receive convergent input from the PVHmp as well as gastric afferent input (vagal), but this input from the PVHmp may also bias the responsiveness of these NST neurons to incoming afferent information. This PVHmp influence on NST excitability is probably mediated by a direct, monosynaptic projection between these two nuclei. These data support the hypothesis that neurons in the PVHmp can control gastric function by altering the sensitivity of neurons which form the sensory limb of gastric vago-vagal reflexes. This ability of the PVHmp to bias the responsiveness of NST neurons to incoming vagal afferent information is probably mediated by a direct, monosynaptic projection between these two nuclei.
进行电生理研究以确定接受来自胃的感觉输入的孤束核（NST）神经元是否会被下丘脑室旁核小细胞内侧部（PVHmp）的微刺激所激活。我们发现，37%被迷走神经刺激正向激活的NST神经元也被PVHmp微刺激正向兴奋。这些NST神经元不仅接受来自PVHmp以及胃传入输入（迷走神经）的汇聚输入，而且来自PVHmp的这种输入还可能使这些NST神经元对传入传入信息的反应性产生偏差。PVHmp对NST兴奋性的这种影响可能是由这两个核之间的直接单突触投射介导的。这些数据支持这样的假设，即PVHmp中的神经元可以通过改变构成胃迷走-迷走反射感觉支的神经元的敏感性来控制胃功能。PVHmp使NST神经元对传入迷走传入信息的反应性产生偏差的这种能力可能是由这两个核之间的直接单突触投射介导的。
