Fenyvesi Ferenc, Klusóczki Ágnes, Rusznyák Ágnes, Zsebik Barbara, Bácskay Ildikó, Váradi Judit
Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary.
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary.
Antioxidants (Basel). 2025 Aug 14;14(8):998. doi: 10.3390/antiox14080998.
Flavonoids play an important role in preventive and therapeutic research due to their significant antioxidant properties. However, their application is limited by several pharmacokinetic drawbacks, such as poor water solubility and low bioavailability. Cyclodextrin-based delivery systems offer an opportunity to overcome these disadvantages. Cyclodextrins are able to form stable, water-soluble inclusion complexes with flavonoids, thereby improving their solubility, chemical stability, and antioxidant activity. This review summarizes the structural characteristics and complexation mechanisms of various flavonoid-cyclodextrin complexes and examines how these interactions influence biological activity. Special attention is given to nanotechnological formulations-such as liposomes, nanofibers, and nanosponges-that enable targeted drug delivery and enhanced therapeutic efficacy. The aim of this review is to provide a comprehensive overview of the role of cyclodextrin-based carriers in the formulation of flavonoids and to highlight the future potential of these systems in modern therapeutics and functional product development.
黄酮类化合物因其显著的抗氧化特性，在预防和治疗研究中发挥着重要作用。然而，它们的应用受到一些药代动力学缺点的限制，如水溶性差和生物利用度低。基于环糊精的递送系统为克服这些缺点提供了契机。环糊精能够与黄酮类化合物形成稳定的水溶性包合物，从而提高其溶解度、化学稳定性和抗氧化活性。本综述总结了各种黄酮类化合物 - 环糊精复合物的结构特征和络合机制，并探讨了这些相互作用如何影响生物活性。特别关注了纳米技术制剂，如脂质体、纳米纤维和纳米海绵，它们能够实现靶向药物递送并提高治疗效果。本综述的目的是全面概述基于环糊精的载体在黄酮类化合物制剂中的作用，并突出这些系统在现代治疗和功能性产品开发中的未来潜力。
