Sokol Maria, Gulayev Ivan, Chirkina Margarita, Klimenko Maksim, Kamaeva Olga, Yabbarov Nikita, Mollaeva Mariia, Nikolskaya Elena
N.M. Emanuel Institute of Biochemical Physics RAS, Moscow 119334, Russia.
Antibiotics (Basel). 2025 Aug 6;14(8):803. doi: 10.3390/antibiotics14080803.
The modern livestock industry incorporates widely used antibiotic growth promoters into animal feed at sub-therapeutic levels to enhance growth performance and feed efficiency. However, this practice contributes to the emergence of antibiotic-resistant pathogens in livestock, which may be transmitted to humans through the food chain, thereby diminishing the efficacy of antibiotics in treating bacterial infections. Current research explores the potential of essential oils from derived medicinal plants as alternative phytobiotics. This review examines modern encapsulation strategies that incorporate essential oils into natural-origin matrices to improve their stability and control their release both in vitro and in vivo. We discuss a range of encapsulation approaches utilizing polysaccharides, gums, proteins, and lipid-based carriers. This review highlights the increasing demand for antibiotic alternatives in animal nutrition driven by regulatory restrictions, and the potential benefits of essential oils in enhancing feed palatability and stabilizing the intestinal microbiome in monogastric animals and ruminants. Additionally, we address the economic viability and encapsulation efficiency of different matrix formulations.
现代畜牧业将广泛使用的抗生素生长促进剂以亚治疗水平添加到动物饲料中,以提高生长性能和饲料效率。然而,这种做法导致家畜中出现抗生素抗性病原体,这些病原体可能通过食物链传播给人类,从而降低抗生素治疗细菌感染的功效。当前的研究探索了源自药用植物的精油作为替代植物源抗生素的潜力。本综述研究了将精油纳入天然来源基质的现代包封策略,以提高其稳定性并控制其在体外和体内的释放。我们讨论了一系列利用多糖、树胶、蛋白质和脂质基载体的包封方法。本综述强调了监管限制推动动物营养中对抗生素替代品的需求不断增加,以及精油在提高单胃动物和反刍动物的饲料适口性和稳定肠道微生物群方面的潜在益处。此外,我们还讨论了不同基质配方的经济可行性和包封效率。