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生物医学中的聚合物药物递送系统

Polymeric Drug Delivery Systems in Biomedicine.

作者信息

Gulyaev Ivan A, Sokol Maria B, Mollaeva Mariia R, Klimenko Maksim A, Yabbarov Nikita G, Chirkina Margarita V, Nikolskaya Elena D

机构信息

Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, 119334, Russia.

出版信息

Biochemistry (Mosc). 2025 Jan;90(Suppl 1):S233-S262. doi: 10.1134/S0006297924603976.

Abstract

Our review examines the key aspects of using polymeric carriers in biomedicine. The section "Polymers for Biomedicine" provides an overview of different types of polymers, their structural features and properties that determine their use as drug delivery vehicles. The section "Polymeric Carriers" characterizes the role of polymeric delivery systems in modern medicine. The main forms of polymeric carriers are described, as well as their key advantages for drug delivery. The section "Preclinical and Clinical Trials of Polymeric Drug Carriers" reviews the examples of clinical and preclinical studies of polymeric forms used for antitumor therapy, therapy for bacterial and infectious diseases. The final section "Targeted Drug Delivery Systems" is devoted to the discussion of approaches, as well as ligands that provide targeted drug delivery using polymeric carriers. We have paid special attention to modern approaches for increasing the efficacy of antibacterial therapy using vector molecules.

摘要

我们的综述探讨了在生物医学中使用聚合物载体的关键方面。“生物医学用聚合物”部分概述了不同类型的聚合物、它们的结构特征以及决定其用作药物递送载体的性质。“聚合物载体”部分描述了聚合物递送系统在现代医学中的作用。介绍了聚合物载体的主要形式及其在药物递送方面的关键优势。“聚合物药物载体的临床前和临床试验”部分回顾了用于抗肿瘤治疗、细菌和传染病治疗的聚合物形式的临床和临床前研究实例。最后一部分“靶向药物递送系统”专门讨论了使用聚合物载体实现靶向药物递送的方法以及配体。我们特别关注了使用载体分子提高抗菌治疗效果的现代方法。

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