Jo Kyeong Min, No Tae-Hoon
Department of Infectious Diseases, Inje University Haeundae Paik Hospital, Busan 48108, Republic of Korea.
Antibiotics (Basel). 2025 Aug 17;14(8):834. doi: 10.3390/antibiotics14080834.
: Antimicrobial stewardship programs (ASPs) are essential for promoting the rational use of antibiotics and combating resistance. In South Korea, implementation has recently accelerated, but real-world data on short-term program performance remain limited. This study evaluated the early outcomes of a newly launched ASP at a tertiary hospital. : This retrospective, single-center study analyzed ASP activity from January to April 2025. Interventions included prospective audit and feedback for restricted antibiotics and recommendations for prolonged antibiotic prescriptions (≥14 days). The primary outcome was the monthly rejection rate of restricted antibiotics. Secondary outcomes included days of therapy (DOT) for restricted antibiotics and the acceptance rate of interventions for prolonged prescriptions. : The monthly rejection rate of restricted antibiotics remained stable between 3.65% and 4.68%. Although the DOT values did not show statistical significance, they demonstrated a moderate inverse correlation with the rejection rate (Pearson's r = -0.868, = 0.132). Among 826 prolonged prescriptions, 513 (62.1%) received ASP intervention. Acceptance of recommendations increased over time, from 67.0% in January to 82.5% in April. Interventions were primarily based on insufficient evidence of infection or inappropriate antibiotic selection. : The newly implemented ASP demonstrated feasibility and early impact in improving antibiotic oversight. Despite the short observation period, the findings suggest a positive influence on prescribing practices. Longer-term studies are needed to evaluate sustained clinical outcomes and broader applicability in diverse healthcare settings.
抗菌药物管理计划（ASPs）对于促进抗生素的合理使用和对抗耐药性至关重要。在韩国，该计划的实施最近有所加速，但关于短期计划绩效的实际数据仍然有限。本研究评估了一家三级医院新启动的抗菌药物管理计划的早期结果。：这项回顾性单中心研究分析了2025年1月至4月的抗菌药物管理计划活动。干预措施包括对限制使用的抗生素进行前瞻性审核和反馈，以及对延长抗生素处方（≥14天）的建议。主要结果是限制使用抗生素的月度驳回率。次要结果包括限制使用抗生素的治疗天数（DOT）以及延长处方干预措施的接受率。：限制使用抗生素的月度驳回率在3.65%至4.68%之间保持稳定。尽管DOT值没有显示出统计学意义，但它们与驳回率呈中度负相关（Pearson相关系数r = -0.868，P = 0.132）。在826份延长处方中，513份（62.1%）接受了抗菌药物管理计划的干预。对建议的接受率随时间增加，从1月份的67.0%增至4月份的82.5%。干预主要基于感染证据不足或抗生素选择不当。：新实施的抗菌药物管理计划在改善抗生素监管方面显示出可行性和早期影响。尽管观察期较短，但研究结果表明对处方实践有积极影响。需要进行长期研究以评估持续的临床结果以及在不同医疗环境中的更广泛适用性。
