Kenesheva Sabina T, Turganbay Seitzhan, Jumagaziyeva Ardak B, Askhatkyzy Gaukhar, Askarova Dana A, Azembayev Amir A, Ilin Alexandr I, Reva Oleg N, Karpenyuk Tatyana A
Scientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.
Biomedicines. 2025 Jul 22;13(8):1790. doi: 10.3390/biomedicines13081790.
The global rise in multidrug resistance underscores the urgent need for the development of novel and effective antimicrobial agents. Semi-organic iodine-containing complexes, owing to their unique properties, low likelihood of resistance development, and stability under various conditions, represent a promising avenue for the design of new therapeutic strategies. This study describes the synthesis of semi-organic iodine-containing complexes and the evaluation of their impact on antibiotic susceptibility modulation in the multidrug-resistant pathogenic microorganisms and . The physicochemical properties of the semiorganic compounds were characterized using UV-Vis spectroscopy, potentiometric, and titrimetric methods. Evaluation of antimicrobial activity was obtained according to CLSI protocols. The impact of semiorganic compounds on the susceptibility of MDR strains was evaluated by the disk diffusion method. This study evaluated the effects of iodine-containing complexes KC-270 and KC-271 on the antibiotic susceptibility of BAA-39 and BAA-196. The most pronounced effect was observed with KC-270 applied during the lag phase, which enhanced the activity of several antibiotics and, in some cases, restored susceptibility. KC-271 exhibited a weaker and more limited impact. The findings suggest that KC-270 has potential as a modulator of antibiotic susceptibility, particularly when administered at early stages of bacterial growth. The results support the ability of amino acid-based iodine coordination compounds to influence the antibiotic susceptibility of pathogenic bacteria, highlighting their potential as adjuvant agents to improve the effectiveness of current antimicrobial therapies. However, although changes in susceptibility were detected, neither compound fully eliminated resistance in the multidrug-resistant strains, indicating the necessity for further research into their mechanisms of action and possible synergistic interactions with antibiotics.
全球多重耐药性的上升凸显了开发新型有效抗菌剂的迫切需求。含半有机碘的配合物因其独特的性质、产生耐药性的可能性低以及在各种条件下的稳定性，代表了设计新治疗策略的一条有前景的途径。本研究描述了含半有机碘配合物的合成及其对多重耐药病原微生物抗生素敏感性调节的影响。使用紫外可见光谱、电位滴定法和滴定法对这些半有机化合物的物理化学性质进行了表征。根据临床和实验室标准协会（CLSI）的方案评估抗菌活性。通过纸片扩散法评估半有机化合物对多重耐药菌株敏感性的影响。本研究评估了含碘配合物KC - 270和KC - 271对BAA - 39和BAA - 196抗生素敏感性的影响。在延迟期应用KC - 270时观察到最显著的效果，它增强了几种抗生素的活性，在某些情况下还恢复了敏感性。KC - 271的影响较弱且更有限。研究结果表明，KC - 270有作为抗生素敏感性调节剂的潜力，特别是在细菌生长早期给药时。这些结果支持了基于氨基酸的碘配位化合物影响病原菌抗生素敏感性的能力，突出了它们作为辅助剂以提高当前抗菌治疗效果的潜力。然而，尽管检测到了敏感性的变化，但两种化合物都没有完全消除多重耐药菌株中的耐药性，这表明有必要进一步研究它们的作用机制以及与抗生素可能的协同相互作用。
