Alemzadeh Kazem, Alemzadeh Joseph
(ESDI) Bionics and Bioengineering Research Group, Faculty of Engineering, School of Electrical, Electronic and Mechanical Engineering, University of Bristol, Bristol BS8 1TR, UK.
Alumnus of the Cardiff University, School of Engineering, Cardiff University, Cardiff CF24 3AA, UK.
Biomedicines. 2025 Jul 24;13(8):1811. doi: 10.3390/biomedicines13081811.
: A critical review of the literature demonstrates that masticatory apparatus with an artificial oral environment is of interest in the fields including (i) dental science; (ii) food science; (iii) the pharmaceutical industries for drug release. However, apparatus that closely mimics human chewing and oral conditions has yet to be realised. This study investigates the vital role of dental morphology and form-function connections using two-bite test parameters for effective drug release from medicated chewing gum (MCG) and compares them to human chewing efficiency with the aid of a humanoid chewing robot and a bionics product lifecycle management (PLM) framework with built-in reverse biomimetics-both developed by the first author. : A novel, bio-engineered two-bite testbed is created for two testing machines with compression and torsion capabilities to conduct two-bite tests for evaluating the mechanical properties of MCGs. : Experimental studies are conducted to investigate the relationship between biting force and crushing/shearing and understand chewing efficiency and effective mastication. This is with respect to mechanochemistry and power stroke for disrupting mechanical bonds releasing the active pharmaceutical ingredients (APIs) of MCGs. The manuscript discusses the effect and the critical role that jaw physiology, dental morphology, the Bennett angle of mandible (BA) and the Frankfort-mandibular plane angle (FMA) on two-bite test parameters when FMA = 0, 25 or 29.1 and BA = 0 or 8. The impact on other scientific fields is also explored.
对文献的批判性综述表明，具有人工口腔环境的咀嚼装置在以下领域具有重要意义：（i）牙科科学；（ii）食品科学；（iii）制药行业的药物释放。然而，尚未实现能紧密模拟人类咀嚼和口腔状况的装置。本研究利用双咬测试参数，研究牙齿形态及形态与功能的联系对含药口香糖（MCG）有效药物释放的重要作用，并借助拟人咀嚼机器人和由第一作者开发的具有内置逆向仿生学的仿生产品生命周期管理（PLM）框架，将其与人类咀嚼效率进行比较。为两台具有压缩和扭转能力的测试机创建了一种新型的生物工程双咬试验台，用于对MCG进行双咬测试以评估其机械性能。开展实验研究以探究咬合力与挤压/剪切力之间的关系，并了解咀嚼效率和有效咀嚼情况。这涉及机械化学和动力冲程，以破坏机械键从而释放MCG的活性药物成分（API）。本文讨论了当下颌前伸运动角（FMA）=0、25或29.1以及Bennett角（BA）=0或8时，颌骨生理学、牙齿形态、下颌Bennett角（BA）和Frankfort-下颌平面角（FMA）对双咬测试参数的影响。还探讨了其对其他科学领域的影响。
