Recław Remigiusz, Suchanecka Aleksandra, Grzywacz Elżbieta, Chmielowiec Krzysztof, Chmielowiec Jolanta, Makarewicz Anna, Łosińska Kinga, Larysz Dariusz, Trybek Grzegorz, Grzywacz Anna
Independent Laboratory of Behavioral Genetics and Epigenetics, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72 St., 70-111 Szczecin, Poland.
Department of Medical Sciences and Public Health, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1 St., 80-336 Gdansk, Poland.
Biomedicines. 2025 Jul 30;13(8):1852. doi: 10.3390/biomedicines13081852.
: Impulsivity is a key psychological construct implicated in the onset and maintenance of behavioural addictions. Dysregulation of impulsivity is central to behavioural addictions, yet its genetic basis remains unclear. This study examined the association between the variable number tandem repeat polymorphism and impulsivity in individuals with behavioural addictions. : A total of 328 males (128 with behavioural addictions and 200 controls) completed the Barratt Impulsiveness Scale. genotyping was performed via PCR and gel electrophoresis. Statistical analyses included chi-square tests, Mann-Whitney U-tests, and two-way ANOVA. : No differences in genotype frequencies were found between groups. However, a significant interaction emerged for attentional impulsivity: individuals with behavioural addictions and the 9/9 genotype had the highest BIS-AI scores (F = 5.48; = 0.0046). : The 9/9 genotype may increase vulnerability to attentional impulsivity, but only in the context of behavioural addictions. These findings highlight a gene-environment interaction and support the role of dopaminergic mechanisms in cognitive dysregulation. Future studies should validate these findings using longitudinal designs and neurobiological methods.
冲动性是一个关键的心理结构,与行为成瘾的发生和维持有关。冲动性失调是行为成瘾的核心,但它的遗传基础仍不清楚。本研究考察了可变数目串联重复多态性与行为成瘾个体冲动性之间的关联。 共328名男性(128名行为成瘾者和200名对照者)完成了巴拉特冲动性量表。通过聚合酶链反应和凝胶电泳进行基因分型。统计分析包括卡方检验、曼-惠特尼U检验和双向方差分析。 两组之间未发现基因型频率的差异。然而,在注意冲动性方面出现了显著的交互作用:行为成瘾者和9/9基因型个体的BIS-AI得分最高(F = 5.48;P = 0.0046)。 9/9基因型可能会增加对注意冲动性的易感性,但仅在行为成瘾的背景下。这些发现突出了基因-环境交互作用,并支持多巴胺能机制在认知失调中的作用。未来的研究应该使用纵向设计和神经生物学方法来验证这些发现。
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