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行为成瘾个体中基因VNTR多态性与冲动性维度之间的关联

Associations Between Gene VNTR Polymorphism and Impulsivity Dimensions in Individuals with Behavioural Addictions.

作者信息

Recław Remigiusz, Suchanecka Aleksandra, Grzywacz Elżbieta, Chmielowiec Krzysztof, Chmielowiec Jolanta, Makarewicz Anna, Łosińska Kinga, Larysz Dariusz, Trybek Grzegorz, Grzywacz Anna

机构信息

Independent Laboratory of Behavioral Genetics and Epigenetics, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72 St., 70-111 Szczecin, Poland.

Department of Medical Sciences and Public Health, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1 St., 80-336 Gdansk, Poland.

出版信息

Biomedicines. 2025 Jul 30;13(8):1852. doi: 10.3390/biomedicines13081852.


DOI:10.3390/biomedicines13081852
PMID:40868105
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12383520/
Abstract

: Impulsivity is a key psychological construct implicated in the onset and maintenance of behavioural addictions. Dysregulation of impulsivity is central to behavioural addictions, yet its genetic basis remains unclear. This study examined the association between the variable number tandem repeat polymorphism and impulsivity in individuals with behavioural addictions. : A total of 328 males (128 with behavioural addictions and 200 controls) completed the Barratt Impulsiveness Scale. genotyping was performed via PCR and gel electrophoresis. Statistical analyses included chi-square tests, Mann-Whitney U-tests, and two-way ANOVA. : No differences in genotype frequencies were found between groups. However, a significant interaction emerged for attentional impulsivity: individuals with behavioural addictions and the 9/9 genotype had the highest BIS-AI scores (F = 5.48; = 0.0046). : The 9/9 genotype may increase vulnerability to attentional impulsivity, but only in the context of behavioural addictions. These findings highlight a gene-environment interaction and support the role of dopaminergic mechanisms in cognitive dysregulation. Future studies should validate these findings using longitudinal designs and neurobiological methods.

摘要

冲动性是一个关键的心理结构,与行为成瘾的发生和维持有关。冲动性失调是行为成瘾的核心,但它的遗传基础仍不清楚。本研究考察了可变数目串联重复多态性与行为成瘾个体冲动性之间的关联。 共328名男性(128名行为成瘾者和200名对照者)完成了巴拉特冲动性量表。通过聚合酶链反应和凝胶电泳进行基因分型。统计分析包括卡方检验、曼-惠特尼U检验和双向方差分析。 两组之间未发现基因型频率的差异。然而,在注意冲动性方面出现了显著的交互作用:行为成瘾者和9/9基因型个体的BIS-AI得分最高(F = 5.48;P = 0.0046)。 9/9基因型可能会增加对注意冲动性的易感性,但仅在行为成瘾的背景下。这些发现突出了基因-环境交互作用,并支持多巴胺能机制在认知失调中的作用。未来的研究应该使用纵向设计和神经生物学方法来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0301/12383520/4faeaa8b3957/biomedicines-13-01852-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0301/12383520/4faeaa8b3957/biomedicines-13-01852-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0301/12383520/4faeaa8b3957/biomedicines-13-01852-g001.jpg

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本文引用的文献

[1]
Exploring Food Addiction Across Several Behavioral Addictions: Analysis of Clinical Relevance.

Nutrients. 2025-4-6

[2]
Exploring the Relationship Between VMAT2 and DAT Expression, Psychotic Experiences, Craving, and Treatment Motivation in Male Patients with Methamphetamine Use Disorder.

J Clin Med. 2024-11-24

[3]
Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance.

Int J Mol Sci. 2024-10-29

[4]
Dopamine and Serotonin Transporter Genes Regulation in Highly Sensitive Individuals during Stressful Conditions: A Focus on Genetics and Epigenetics.

Biomedicines. 2024-9-23

[5]
Resting-state brain networks alterations in adolescents with Internet Gaming Disorder associate with cognitive control impairments.

Front Psychiatry. 2024-9-9

[6]
Characteristics of Adolescents with and without a Family History of Substance Use Disorder from a Minority Cohort.

Children (Basel). 2024-5-31

[7]
Gene-Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes.

Int J Mol Sci. 2024-4-10

[8]
Differential Neural Correlates in the Prefrontal Cortex during a Delay Discounting Task in Healthy Adults: An fNIRS Study.

Brain Sci. 2023-5-3

[9]
DNA Methylation of the Dopamine Transporter Gene-Bliss Seekers in the Light of Epigenetics.

Int J Mol Sci. 2023-3-9

[10]
Theorizing the Role of Dopaminergic Polymorphic Risk Alleles with Intermittent Explosive Disorder (IED), Violent/Aggressive Behavior and Addiction: Justification of Genetic Addiction Risk Severity (GARS) Testing.

J Pers Med. 2022-11-23

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