Spanjaard L, Bol P, Ekker W, Zanen H C
J Infect. 1985 Nov;11(3):259-68. doi: 10.1016/s0163-4453(85)93327-4.
Data on the incidence of bacterial meningitis (BM) in the Netherlands are important for a cost-benefit analysis of new effective vaccines. During the period 1977-1982 we compared the notifications of meningococcal meningitis, diagnoses on discharge from hospital of all causes of BM (Stichting Medische Registratie, Medical Registration Foundation; SMR) and bacteriological data (Netherlands Reference Laboratory for Bacterial Meningitis; RBM). Notifications of meningococcal meningitis were 42% lower than SMR-data. RBM-registration of meningococcal, haemophilus and pneumococcal meningitis was 20% lower than SMR. Reviewing patient-records we found that these diseases had not been reported in 16% (RBM) and 11% (SMR) of cases. We estimate the incidence of BM during an endemic period at 8.0 per 100 000 population per year, to which the meningococcus contributes 20-25%. In children under 5 years of age the age-specific incidence of haemophilus meningitis is 22/100 000.
荷兰细菌性脑膜炎（BM）发病率的数据对于新型有效疫苗的成本效益分析至关重要。在1977年至1982年期间，我们比较了脑膜炎球菌性脑膜炎的报告病例、所有病因的BM出院诊断病例（医学注册基金会；SMR）以及细菌学数据（荷兰细菌性脑膜炎参考实验室；RBM）。脑膜炎球菌性脑膜炎的报告病例比SMR数据低42%。脑膜炎球菌、嗜血杆菌和肺炎球菌性脑膜炎的RBM登记病例比SMR低20%。通过查阅患者记录，我们发现这些疾病在16%（RBM）和11%（SMR）的病例中未被报告。我们估计在流行期间BM的发病率为每年每10万人口8.0例，其中脑膜炎球菌占20%-25%。在5岁以下儿童中，嗜血杆菌性脑膜炎的年龄特异性发病率为每10万人口22例。
