Tanaka H, Kimura E, Onda T, Ishida N, Tenjin Y
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Dec;37(12):2681-90.
230 cases of mild dysplasia, detected in examinations for cancer of the uterus, were followed up cytologically, and colposcopically for more than 2 and a maximum of 10 years, and the following results were obtained: Mild dysplasia resulted in regression in 169 cases (73.5%), persistence in 46 cases (20.0%), and progression in 15 cases (6.5%). Out of the group with progression, 10 cases (4.3%) developed into carcinoma in situ or microinvasive carcinoma. The average period required for the progression was 54.8 months. The combined use of cytology and colposcopy is useful for diagnosis and follow up of mild dysplasia. In the combined use of cytology and colposcopy, it is appropriate to evaluate the outcome (progression or regression) of mild dysplasia 2 years after detection. The transformation ratio at the time of the initial examination was in many cases higher in the progression group than in the regression group. In the progression group an increase in the transformation ratio was noted in all cases, and it appears that it is also necessary to pay attention to changes in the transformation ratio, in addition to the grading of the findings.
在子宫癌检查中检测出的230例轻度发育异常病例，进行了长达2年至最长10年的细胞学和阴道镜随访，结果如下：169例（73.5%）轻度发育异常出现消退，46例（20.0%）持续存在，15例（6.5%）进展。在进展组中，10例（4.3%）发展为原位癌或微浸润癌。进展所需的平均时间为54.8个月。细胞学和阴道镜联合应用对轻度发育异常的诊断和随访有用。在细胞学和阴道镜联合应用中，在检测后2年评估轻度发育异常的转归（进展或消退）是合适的。初始检查时的转化率在进展组中在许多情况下高于消退组。在进展组中所有病例均发现转化率增加，除了对检查结果进行分级外，似乎还需要关注转化率的变化。
