Herbeck G
Fortschr Med. 1979 Mar 22;97(11):481-6.
A comparative study shows high incidence of preclinical cancerous lesions of the uterine cervix in women under thirty years of age. The rate of positive cytology in this age group was the same as in the group of women over thirty (0.3 per cent each). The histological findings revealed intraepithelial lesions like dysplasia and carcinoma in situ in the younger group compared to more advanced lesions like microinvasive cancer in the higher-aged group. The use of colposcopy rendered optical evidence--predominantly in the younger group--of lesions which under long-term observation preceded positive cytology for years as well as the consequent histological proof of dysplasia and preclinical carcinoma. As a result of the given and discussed clinical data in both compared age groups the value of colposcopy is stressed in improving the quality of detection of preclinical neoplasia in the uterine cervix and the necessity of cancer-screening in younger-aged women is emphasized.
一项对比研究表明,30岁以下女性子宫颈临床前癌前病变的发生率很高。该年龄组的细胞学阳性率与30岁以上女性组相同(均为0.3%)。组织学检查结果显示,较年轻组存在发育异常和原位癌等上皮内病变,而较高年龄组则存在微浸润癌等更晚期病变。阴道镜检查的应用提供了光学证据——主要在较年轻组——显示这些病变在长期观察中在细胞学阳性出现前数年就已存在,随后还有发育异常和临床前癌的组织学证据。鉴于两个对比年龄组给出并讨论的临床数据,强调了阴道镜检查在提高子宫颈临床前肿瘤检测质量方面的价值,并强调了年轻女性进行癌症筛查的必要性。