Alwaili Maha Abdullah, Eid Thamir M, Abu-Almakarem Amal S, Alsirhani Alaa Muqbil, Al-Sowayan Noorah Saleh, Aljarari Rabab Mohamed, Al-Judaibi Effat A, AlRashidi Aljazi Abdullah, Mobasher Maysa A, El-Said Karim Samy
Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Int J Mol Sci. 2025 Aug 12;26(16):7779. doi: 10.3390/ijms26167779.
Syringic acid (SYA) is a significant phenolic compound with the potential for various biomedical uses, including uses of its hepatoprotective properties. Doxorubicin (DOX) is a drug used in the treatment of several tumors, but its side effects, particularly hepatotoxicity, limit its effectiveness. This study investigated the therapeutic effects of SYA on DOX-induced hepatic injury in rats. Molecular docking studies were performed using AutoDock Vina. Five groups of Sprague-Dawley rats (eight in each group) were studied. Gp1 was a negative control group; Gps2-5 was administered intraperitoneally (i.p.) with DOX at a dosage of 4 mg/kg once a week for a month; and Gp2 was left as a positive control group. Gps3-5 received oral SYA at doses of 25, 50, or 75 mg/kg/day, respectively, for a month. Histopathological, molecular, and biochemical analyses were conducted one month after the last SYA dosages were given. The findings demonstrated that by reversing biochemical changes and reducing oxidative stress and inflammation, SYA therapy considerably reduced DOX-induced hepatotoxicity in rats. These results implied that SYA may lessen the hepatotoxicity that DOX causes in rats.
丁香酸（SYA）是一种重要的酚类化合物，具有多种生物医学用途的潜力，包括其保肝特性的应用。阿霉素（DOX）是一种用于治疗多种肿瘤的药物，但其副作用，尤其是肝毒性，限制了其有效性。本研究调查了SYA对大鼠阿霉素诱导的肝损伤的治疗作用。使用AutoDock Vina进行分子对接研究。研究了五组Sprague-Dawley大鼠（每组八只）。Gp1为阴性对照组；Gps2-5每周一次腹腔注射（i.p.）4 mg/kg剂量的DOX，持续一个月；Gp2作为阳性对照组。Gps3-5分别以25、50或75 mg/kg/天的剂量口服SYA，持续一个月。在最后一次给予SYA剂量一个月后进行组织病理学、分子和生化分析。研究结果表明，通过逆转生化变化、减轻氧化应激和炎症，SYA治疗可显著降低阿霉素诱导的大鼠肝毒性。这些结果表明SYA可能减轻阿霉素对大鼠造成的肝毒性。
