"Two-route chemotherapy" using high-dose intra-arterial cis-diamminedichloroplatinum (II) and systemic sodium thiosulfate, its antidote, for rat limb tumor.

The effect of "two-route chemotherapy (TRC)" using a combination of cis-diamminedichloroplatinum (II) (DDP) and its antidote, sodium thiosulfate (STS) on rat limb tumor was studied. TRC in which 20 mg/kg of DDP and two doses of 1,054 mg/kg of STS (100-fold molar ratio to DDP) were given via the femoral artery and the femoral vein, respectively, provided significantly better antitumor effects evaluated by tumor weight than did intra-arterial or intra-venous DDP (5 mg/kg) without STS. Side effects were evaluated by the BUN levels and by changes in body weight after the treatments. In the group of TRC, increase in BUN levels was protected completely and body weight loss was slight.