Uozumi J, Sagiyama K, Aoki K, Iwamoto Y, Baba T
Cancer Treat Rep. 1983 Dec;67(12):1067-74.
The therapeutic efficacy of "two-route chemotherapy" (TRC) using cisplatin (DDP) and its potent antidote, sodium thiosulfate (STS), was studied on rat metastatic liver tumors. Twenty mg/kg of DDP was given to rats via the hepatic artery in combination with systemic STS at a dose of 1054 mg/kg (100-fold molar ratio to 20 mg/kg of DDP) or at two doses of 1054 mg/kg. As controls, 5 or 4 mg/kg of DDP alone was given intra-arterially or iv. Antitumor effects were evaluated by prolongation in lifespan after the tumor cell inoculation. Side effects were assessed by weight loss, BUN, and serum transaminases after the chemotherapy. TRC resulted in the longest lifespan, with a minimum weight loss and without elevation of BUN or serum transaminases. The therapeutic efficacy of TRC was enhanced by temporary ligation of the portal vein for 5 minutes, performed simultaneously with DDP infusion. Our findings clearly indicate the effectiveness of TRC using intra-arterial DDP in a high dose and in combination with iv STS.
我们研究了使用顺铂（DDP）及其强效解毒剂硫代硫酸钠（STS）的“双途径化疗”（TRC）对大鼠转移性肝肿瘤的治疗效果。给大鼠经肝动脉注射20mg/kg的DDP，并联合静脉注射1054mg/kg的STS（与20mg/kg的DDP的摩尔比为100倍）或分两次注射1054mg/kg的STS。作为对照，分别经动脉内或静脉内单独给予5或4mg/kg的DDP。通过接种肿瘤细胞后生存期的延长来评估抗肿瘤效果。通过化疗后的体重减轻、血尿素氮（BUN）和血清转氨酶来评估副作用。TRC使大鼠生存期最长，体重减轻最少，且BUN或血清转氨酶没有升高。在输注DDP的同时，对门静脉进行5分钟的临时结扎，可增强TRC的治疗效果。我们的研究结果清楚地表明，高剂量动脉内注射DDP并联合静脉注射STS的TRC是有效的。
