Price W H, Clayton J F, Wilson J, Collyer S, De Mey R
J Epidemiol Community Health. 1985 Dec;39(4):330-6. doi: 10.1136/jech.39.4.330.
The causes of death in 466 X chromatin positive males (Klinefelter's syndrome) studied prospectively over the last 25 years have been analysed. We have previously reported the overall mortality to be increased by 50% and life expectancy reduced by about five years. A highly significant increase in mortality from cerebrovascular disease was observed in the sub group considered to be most representative of X chromatin positive males in general. In the age group up to 45 years this increase could be attributed to deaths from subarachnoid haemorrhage. An increase in mortality from respiratory diseases was observed in those ascertained in psychiatric hospitals. In the sample as a whole there were small but highly significant numbers of deaths from carcinoma of the breast and aortic valve disease. The deaths from carcinoma of the breast were comparable with those expected if female mortality rates were applied.
对过去25年进行前瞻性研究的466名X染色质阳性男性（克兰费尔特综合征）的死亡原因进行了分析。我们之前曾报道，总体死亡率增加了50%，预期寿命缩短了约5年。在被认为是一般X染色质阳性男性最具代表性的亚组中，观察到脑血管疾病死亡率显著增加。在45岁及以下年龄组，这种增加可归因于蛛网膜下腔出血导致的死亡。在精神病院确诊的患者中，观察到呼吸系统疾病死亡率增加。在整个样本中，乳腺癌和主动脉瓣疾病导致的死亡人数虽少，但具有高度显著性。乳腺癌导致的死亡人数与应用女性死亡率时预期的死亡人数相当。
