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X染色体阳性男性的死亡率和预期寿命。

Mortality ratios and life expectancy in X chromatin positive males.

作者信息

Price W H, Clayton J F, Collyer S, de Mey R

出版信息

J Epidemiol Community Health. 1985 Mar;39(1):33-8. doi: 10.1136/jech.39.1.33.

DOI:10.1136/jech.39.1.33
PMID:4039353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1052397/
Abstract

In a prospective study of 466 X chromatin positive males an increase in mortality of about 50% has been observed. The increase is associated with a loss of about five years in life span. There is no convincing evidence that the increase is concentrated at any particular age group but this possibility could not be excluded. No effect of mode of ascertainment could be demonstrated. From this study we conclude that it is likely that the mortality experienced by chromatin positive males in general is at least 115% of that experienced by normal men and could be more than 200%.

摘要

在一项对466名X染色质阳性男性的前瞻性研究中,观察到死亡率增加了约50%。这种增加与寿命缩短约五年有关。没有令人信服的证据表明这种增加集中在任何特定年龄组,但这种可能性不能排除。未证明确定方式有任何影响。从这项研究中我们得出结论,一般来说,染色质阳性男性的死亡率很可能至少是正常男性的115%,甚至可能超过200%。

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本文引用的文献

1
SEX-CHROMOSOME ABNORMALITIES IN NEWBORN BABIES.新生儿性染色体异常
Lancet. 1964 Feb 8;1(7328):286-90. doi: 10.1016/s0140-6736(64)92405-5.
2
A case of human intersexuality having a possible XXY sex-determining mechanism.一例可能具有XXY性别决定机制的人类两性畸形病例。
Nature. 1959 Jan 31;183(4657):302-3. doi: 10.1038/183302a0.
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Cytologic tests of sex in congenital testicular hypoplasia.先天性睾丸发育不全的性细胞学检查
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Chromatin test in Klinefelter's syndrome.
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[Sex chromosome abnormalities in dead and stillborn children].[死胎和死产儿中的性染色体异常]
Tsitologiia. 1966 Mar-Apr;8(2):215-21.
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Evaluation of survival data and two new rank order statistics arising in its consideration.生存数据的评估以及在考虑过程中出现的两个新的排序统计量。
Cancer Chemother Rep. 1966 Mar;50(3):163-70.
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Sex chromosome aneuploidy in man and its frequency, with special reference to mental subnormality and criminal behavior.人类性染色体非整倍体及其频率,特别涉及智力低下和犯罪行为
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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.需要对每位患者进行长期观察的随机临床试验的设计与分析。II. 分析与示例。
Br J Cancer. 1977 Jan;35(1):1-39. doi: 10.1038/bjc.1977.1.