Chung Sang Wan
Division of Rheumatology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.
J Clin Med. 2025 Aug 18;14(16):5827. doi: 10.3390/jcm14165827.
Rheumatic diseases encompass various autoimmune and inflammatory conditions affecting the joints, muscles, and connective tissues. Recent studies have advanced our understanding of the molecular pathogenesis of rheumatic diseases and have led to the identification of several promising therapeutic targets, paving the way for the development of novel drug interventions. This review highlights the latest molecular advances in rheumatoid arthritis, with a particular focus on innovative therapeutic strategies, and presents new perspectives on their management, including cytokines, intracellular signaling pathways, immune checkpoints, and novel cell-based therapies. A better understanding of these targets is essential for developing effective and personalized treatments.
风湿性疾病包括各种影响关节、肌肉和结缔组织的自身免疫性和炎症性病症。最近的研究加深了我们对风湿性疾病分子发病机制的理解，并导致了几个有前景的治疗靶点的识别，为新型药物干预的开发铺平了道路。本综述重点介绍类风湿关节炎的最新分子进展，特别关注创新治疗策略，并就其管理提出新观点，包括细胞因子、细胞内信号通路、免疫检查点和新型细胞疗法。更好地理解这些靶点对于开发有效和个性化治疗至关重要。
