Sun Tunahan, Dursun Çakar Demet, Yeşiloğlu Caner, Demirkol Mehmet Emin, Tamam Lut, Uğur Kerim, Polat Hatice
Department of Psychiatry, Düziçi State Hospital, Osmaniye 80600, Turkey.
Department of Ophthalmology, Düziçi State Hospital, Osmaniye 80600, Turkey.
J Clin Med. 2025 Aug 20;14(16):5886. doi: 10.3390/jcm14165886.
: Borderline personality disorder (BPD) is a psychiatric disorder characterized by emotional instability, impulsive behavior, and impaired interpersonal relationships. It is associated with a high prevalence of childhood trauma and neurobiological changes. This study aimed to compare ophthalmologic parameters, namely, optic nerve sheath diameter, intraocular pressure, and dry eye, in patients with BPD with healthy controls and to investigate the relations between these parameters and childhood trauma. : This study included 51 female patients with BPD between the ages of 18 and 35 years, who were not using psychotropic medication, and 51 healthy controls matched for age and educational level. Optic nerve sheath diameter, intraocular pressure, and tear break-up time were measured, and trauma history was evaluated using the Childhood Trauma Questionnaire-Short Form. Independent -test and Pearson correlation analysis were used in statistical analyses. : Patients with BPD were found to have significantly higher mean optic nerve sheath diameter scores (left: 3.94 ± 0.43, right: 3.97 ± 0.47) compared with healthy controls (left: 3.76 ± 0.44, right: 3.78 ± 0.45) ( < 0.05). The groups showed no significant difference in intraocular pressure and dry eye parameters ( > 0.05). A significant positive correlation was noted between emotional abuse scores and the optic nerve sheath diameter of the left eye in patients with BPD ( < 0.05; r = 0.364). : An increased optic nerve sheath diameter may be a potential peripheral biomarker reflecting chronic stress or changes in intracranial physiology in patients with BPD. This increase is particularly associated with a history of emotional abuse. Ophthalmological parameters may contribute to understanding the neurobiological basis of BPD and serve as peripheral biomarkers or indicators of neurobiological changes.
边缘型人格障碍（BPD）是一种精神疾病，其特征为情绪不稳定、冲动行为和人际关系受损。它与童年创伤的高患病率以及神经生物学变化有关。本研究旨在比较BPD患者与健康对照者的眼科参数，即视神经鞘直径、眼压和干眼情况，并探讨这些参数与童年创伤之间的关系。：本研究纳入了51名年龄在18至35岁之间、未使用精神药物的女性BPD患者，以及51名年龄和教育水平相匹配的健康对照者。测量了视神经鞘直径、眼压和泪膜破裂时间，并使用儿童创伤问卷简表评估创伤史。统计分析采用独立样本t检验和Pearson相关分析。：发现BPD患者的平均视神经鞘直径得分显著高于健康对照者（左眼：3.94±0.43，右眼：3.97±0.47）（健康对照者左眼：3.76±0.44，右眼：3.78±0.45）（P<0.05）。两组在眼压和干眼参数方面无显著差异（P>0.05）。BPD患者中，情感虐待得分与左眼视神经鞘直径之间存在显著正相关（P<0.05；r=0.364）。：视神经鞘直径增加可能是反映BPD患者慢性应激或颅内生理变化的潜在外周生物标志物。这种增加尤其与情感虐待史有关。眼科参数可能有助于理解BPD的神经生物学基础，并作为神经生物学变化的外周生物标志物或指标。
