Brown Amanda, Dias Ingrid, da Silva Novaes Jefferson, Sant'Ana Leandro, Felix Bruno Perez, Cahuê Fabio, Brito-Azevedo Anderson, Reis Michel Silva, Lopes Agnaldo José, Salerno Verônica, Simão Roberto, Monteiro Estêvão Rios, Perez Renata de Mello
Federal Institute of Southeast Minas Gerais-Campus Barbacena, Barbacena 36205-018, Brazil.
Postgraduate Program in Physical Education (PPGEF), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Int J Environ Res Public Health. 2025 Aug 11;22(8):1257. doi: 10.3390/ijerph22081257.
Cirrhosis represents an advanced stage of hepatic fibrosis, and the metabolic changes resulting from liver dysfunction can cause impairment in physical capacity and quality of life. This study aimed to evaluate the effect of 12 weeks of resistance exercise on inflammatory markers, oxidative stress, physical conditioning, and quality of life in patients with liver cirrhosis.
A total of 38 patients paired in the exercise (EG) and control (CG) groups participated in this study. The EG submitted to two weekly sessions of a program composed of resistance exercises. We evaluated the inflammatory markers (IL-6, IL-10, and TNF-α), oxidative stress (carbonylated protein, total thiols, enzyme superoxide dismutase, and catalase activity), body composition, handgrip strength (HGS), total volume of training, cardiorespiratory capacity (VO, VCO, and VE), exercise capacity, and quality of life.
Regarding the EG, when comparing the follow-up period to the baseline, significant differences ( < 0.05) were found in BMI, HGS, total training volume, cardiorespiratory capacity variables, the 6 min walk test, and quality of life. Improvements were observed, without significant differences, in the inflammatory profile, oxidative stress, and one of the markers of liver function. The CG showed a significant decrease ( < 0.05) in HGS and cardiorespiratory capacity after the intervention.
In patients with liver cirrhosis, a resistance exercise program improved physical fitness and quality of life, without adverse events. In addition, it seems that this type of training can bring some benefit to the inflammatory profile and oxidative stress of this population.
肝硬化代表肝纤维化的晚期阶段，肝功能障碍引起的代谢变化可导致身体能力和生活质量受损。本研究旨在评估为期12周的抗阻运动对肝硬化患者炎症标志物、氧化应激、身体状况和生活质量的影响。
共有38名患者被配对分为运动组（EG）和对照组（CG）参与本研究。运动组每周进行两次由抗阻运动组成的训练课程。我们评估了炎症标志物（白细胞介素-6、白细胞介素-10和肿瘤坏死因子-α）、氧化应激（羰基化蛋白、总巯基、超氧化物歧化酶和过氧化氢酶活性）、身体成分、握力（HGS）、总训练量、心肺功能（VO、VCO和VE）、运动能力和生活质量。
关于运动组，将随访期与基线期进行比较时，在体重指数、握力、总训练量、心肺功能变量、6分钟步行试验和生活质量方面发现了显著差异（<0.05）。在炎症指标、氧化应激和肝功能标志物之一方面观察到了改善，但无显著差异。干预后，对照组的握力和心肺功能显著下降（<0.05）。
在肝硬化患者中，抗阻运动计划可改善身体素质和生活质量，且无不良事件。此外，这种类型的训练似乎可以给该人群的炎症指标和氧化应激带来一些益处。
