Kim Sang-Dol, Yeun Young-Ran
Department of Nursing, College of Health Science, Kangwon National University, Samcheok 25949, Korea.
Int J Environ Res Public Health. 2022 Mar 14;19(6):3434. doi: 10.3390/ijerph19063434.
Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults.
伴随衰老出现的慢性低度炎症与不良健康后果相关，并且可能会加重诸如COVID-19等传染病的严重程度。抗阻训练（RT）有改善慢性低度炎症的潜力，但证据仍不确凿。本研究评估了抗阻训练对老年人慢性低度炎症的影响。检索了MEDLINE、EMBASE、Cochrane图书馆、CINAHL、RISS、NDSL和KoreaMed。我们纳入了评估抗阻训练对60岁及以上人群C反应蛋白（CRP）、白细胞介素（IL）-6、IL-10和肿瘤坏死因子（TNF）-α影响的研究。使用固定效应或随机效应模型估计效应量。针对年龄、健康状况、训练方法、练习次数、强度、每周频率和持续时间进行了亚组分析。在纳入的18项随机对照试验（539例患者）中，抗阻训练对减轻老年人的CRP（效应量=-0.72，95%置信区间=-1.06至-0.38，p<0.001）、IL-10（-3.34，-6.16至-0.53，p=0.02）和TNF-α（-0.56，-1.08至-0.03，p=0.04）有效，并且有降低IL-6的趋势（-0.59，-1.18至0.00，p=0.05）。亚组分析显示，无论年龄、训练方法、练习次数、强度、每周频率和持续时间如何，CRP均降低。抗阻训练可用于改善老年人的慢性低度炎症。
