强直性肌营养不良患者红细胞、单核细胞和血浆的脂肪酸组成

Fatty acid compositions of erythrocytes, mononuclear cells and blood plasma of patients with myotonic dystrophy.

作者信息

Antoku Y, Sakai T, Goto I, Iwashita H, Kuroiwa Y

出版信息

J Neurol Sci. 1985 Dec;71(2-3):387-93. doi: 10.1016/0022-510x(85)90077-2.

Abstract

Fatty acid compositions of erythrocyte membrane phospholipids including phosphatidylethanolamine subclasses, blood plasma and mononuclear cells of 8 patients with myotonic dystrophy (MyD) and 8 normal controls were analyzed by high performance liquid chromatography. Slight changes (decreased C18:2 and increased C16:0) in the fatty acid compositions of erythrocyte membrane glycerophospholipids and blood plasma lipids were observed in MyD. There was no significant difference in the fatty acid composition of mononuclear cells between MyD and normal controls. It seems that no essential defect exists in either the erythrocyte membrane fatty acid composition or the fatty acid metabolism itself in MyD.

摘要

采用高效液相色谱法分析了8例强直性肌营养不良（MyD）患者和8例正常对照者红细胞膜磷脂（包括磷脂酰乙醇胺亚类）、血浆及单核细胞的脂肪酸组成。在MyD患者中，观察到红细胞膜甘油磷脂和血浆脂质的脂肪酸组成有轻微变化（C18:2减少，C16:0增加）。MyD患者与正常对照者单核细胞的脂肪酸组成无显著差异。似乎MyD患者的红细胞膜脂肪酸组成或脂肪酸代谢本身均不存在本质缺陷。