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糖尿病对肋骨骨折手术固定术后围手术期结局的影响:一项国民健康保险研究数据库分析

Influence of Diabetes Mellitus on Perioperative Outcomes Following Surgical Stabilization of Rib Fractures: A National Health Insurance Research Database Analysis.

作者信息

Liu Yang-Fan, Chen Te-Li, Guo Jian-Wei, Liu Shih-Ching, Wang Wen-Ching

机构信息

Department of Traumatology, Hsinchu MacKay Memorial Hospital, Hsinchu 300044, Taiwan.

Department of Thoracic Surgery, Hsinchu MacKay Memorial Hospital, Hsinchu 300044, Taiwan.

出版信息

Medicina (Kaunas). 2025 Jul 26;61(8):1358. doi: 10.3390/medicina61081358.

DOI:10.3390/medicina61081358
PMID:40870403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12387593/
Abstract

Diabetes mellitus (DM) significantly impacts post-surgical recovery and fracture healing; however, few studies have specifically investigated the impact of DM on outcomes in patients undergoing surgical stabilization of rib fractures (SSRF). This study investigated the potential influence of DM on perioperative outcomes following SSRF, using data from Taiwan's National Health Insurance Research Database (NHIRD). Data of 1603 patients with multiple rib fractures who underwent SSRF between 2001 and 2019 were retrospectively analyzed. Patients were categorized into three groups: no DM, DM without chronic complications, and DM with chronic complications. The associations between DM status and perioperative outcomes, including hospital length of stay (LOS), in-hospital mortality, readmission rates, and complications such as pneumonia, surgical site infection (SSI), acute myocardial infarction (AMI), and total hospital costs were determined using univariate and multivariable regression analyses. The mean age of the 1603 patients was 52.0 years, and 71% were male. Patients with DM and chronic complications had higher risks of 14-day readmission (adjusted odds ratio [aOR] = 2.99; 95% confidence interval [CI]: 1.18-7.62), 15-30 day readmission (aOR = 3.28; 95% CI: 1.25-8.60), SSI (aOR = 2.90; 95% CI: 1.37-6.14), AMI (aOR = 3.44; 95% CI: 1.28-9.24), and acute respiratory distress syndrome (ARDS) (aOR = 1.96; 95% CI: 1.03-3.74). In conclusion, DM, particularly DM with chronic complications, significantly increases the risk of adverse short-term outcomes following SSRF. These findings emphasize the need for enhanced care for patients with DM to optimize the outcomes of SSRF.

摘要

糖尿病(DM)对术后恢复和骨折愈合有显著影响;然而,很少有研究专门调查DM对肋骨骨折手术固定(SSRF)患者预后的影响。本研究利用台湾国民健康保险研究数据库(NHIRD)的数据,调查了DM对SSRF围手术期预后的潜在影响。对2001年至2019年间接受SSRF的1603例多根肋骨骨折患者的数据进行了回顾性分析。患者被分为三组:无DM、无慢性并发症的DM和有慢性并发症的DM。使用单因素和多变量回归分析确定DM状态与围手术期预后之间的关联,包括住院时间(LOS)、院内死亡率、再入院率以及肺炎、手术部位感染(SSI)、急性心肌梗死(AMI)等并发症和总住院费用。1603例患者的平均年龄为52.0岁,71%为男性。有慢性并发症的DM患者14天再入院风险更高(调整优势比[aOR]=2.99;95%置信区间[CI]:1.18-7.62),15-30天再入院风险更高(aOR=3.28;95%CI:1.25-8.60),SSI风险更高(aOR=2.90;95%CI:1.37-6.14),AMI风险更高(aOR=3.44;95%CI:1.28-9.24),以及急性呼吸窘迫综合征(ARDS)风险更高(aOR=1.96;95%CI:1.03-3.74)。总之,DM,尤其是伴有慢性并发症的DM,显著增加了SSRF后不良短期预后的风险。这些发现强调了加强对DM患者的护理以优化SSRF预后的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66a9/12387593/7ada01b99427/medicina-61-01358-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66a9/12387593/7ada01b99427/medicina-61-01358-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66a9/12387593/7ada01b99427/medicina-61-01358-g001.jpg

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本文引用的文献

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Time to surgical stabilization of rib fractures: does it impact outcomes?肋骨骨折手术固定的时机:它会影响治疗结果吗?
Trauma Surg Acute Care Open. 2024 Jul 11;9(1):e001233. doi: 10.1136/tsaco-2023-001233. eCollection 2024.
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Unveiling the hidden burden: the impact of undiagnosed comorbidities on health-related quality of life in ICU survivors.揭示隐藏的负担:未诊断出的合并症对重症监护病房幸存者健康相关生活质量的影响。
Crit Care. 2024 Jul 10;28(1):229. doi: 10.1186/s13054-024-05025-8.
3
Higher mortality and longer length of stay in hospitalized patients with newly diagnosed diabetes.
新诊断为糖尿病的住院患者死亡率更高,住院时间更长。
Diabetes Res Clin Pract. 2024 Apr;210:111601. doi: 10.1016/j.diabres.2024.111601. Epub 2024 Mar 2.
4
Impact of obesity on outcomes after surgical stabilization of multiple rib fractures: Evidence from the US nationwide inpatient sample.肥胖对多发性肋骨骨折手术后结局的影响:来自美国全国住院患者样本的证据。
PLoS One. 2024 Feb 29;19(2):e0299256. doi: 10.1371/journal.pone.0299256. eCollection 2024.
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Diabetes and the Microvasculature of the Bone and Marrow.糖尿病与骨骼和骨髓的微血管
Curr Osteoporos Rep. 2024 Feb;22(1):11-27. doi: 10.1007/s11914-023-00841-3. Epub 2024 Jan 10.
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Perioperative considerations for patients undergoing surgical stabilization of rib fractures: A narrative review.手术固定肋骨骨折患者的围手术期注意事项:叙述性综述。
J Clin Anesth. 2023 Dec;91:111275. doi: 10.1016/j.jclinane.2023.111275. Epub 2023 Oct 3.
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Outcomes of surgical stabilization of rib fractures in a minority population: Retrospective analysis of a case series from an acute care facility.少数族裔人群肋骨骨折手术固定的结果:对一家急症护理机构一系列病例的回顾性分析。
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