Wang Gang, Yang Feifei, Zhou Weiying, Xiao Nanyang, Luo Mao, Tang Zonghao
Laboratory for Cardiovascular Pharmacology of Department of Pharmacology, The School of Pharmacy, Southwest Medical University, Luzhou, China; Drug Discovery Research Center, Southwest Medical University, Luzhou, China; Department of Pharmacology, college of Pharmacy, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Drug Metabolism, Key Laboratory for Biochemistry and Molecular Pharmacology of Chongqing, Chongqing, China, Chongqing, China.
Department of Pharmacology, college of Pharmacy, Chongqing Medical University, Chongqing, China.
Biomed Pharmacother. 2023 Jan;157:114004. doi: 10.1016/j.biopha.2022.114004. Epub 2022 Nov 11.
When the production of reactive oxygen species (ROS) is overloaded surpassing the capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage termed oxidative stress (OS). This phenomenon is ubiquitously detected in many human pathological conditions. Wound healing program implicates continuous neovascularization, cell proliferation, and wound remodeling. Increasing evidence indicates that reactive oxygen species (ROS) have profound impacts on the wound healing process through regulating a series of the physiological and pathological program including inflammatory response, cell proliferation, angiogenesis, granulation as well as extracellular matrix formation. In most pathological wound healing processes, excessive ROS exerts a negative role on the wound healing process. Interestingly, the moderate increase of ROS levels is beneficial in killing bacteria at the wound site, which creates a sterile niche for revascularization. In this review, we discussed the physiological rhythms of wound healing and the role of ROS in this progress, aim to explore the potential manipulation of OS as a promising therapeutic avenue.
当活性氧（ROS）的产生过载，超过还原调节系统的能力时，哺乳动物细胞会经历一系列称为氧化应激（OS）的氧化损伤。这种现象在许多人类病理状况中普遍存在。伤口愈合过程涉及持续的新血管形成、细胞增殖和伤口重塑。越来越多的证据表明，活性氧（ROS）通过调节一系列生理和病理过程，包括炎症反应、细胞增殖、血管生成、肉芽组织形成以及细胞外基质形成，对伤口愈合过程产生深远影响。在大多数病理性伤口愈合过程中，过量的ROS对伤口愈合过程起负面作用。有趣的是，ROS水平的适度升高有利于杀死伤口部位的细菌，从而为血管再生创造一个无菌环境。在这篇综述中，我们讨论了伤口愈合的生理节律以及ROS在这一过程中的作用，旨在探索将氧化应激作为一种有前景的治疗途径进行潜在调控的方法。
